SCN1A
| Description | Sodium channel protein type 1 subunit alpha |
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Gene and Protein Information
| Gene ID | 6323 |
|---|---|
| Uniprot Accession IDs | E9PG49 Q16172 Q585T7 Q8IUJ6 Q96LA3 Q9C008 |
| Ensembl ID | ENSP00000303540 |
| Symbol | NAC1 SCN1 FEB3 FHM3 NAC1 SCN1 SMEI EIEE6 FEB3A HBSCI GEFSP2 Nav1.1 |
| Family | Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.1/SCN1A subfamily. |
| Sequence | MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK Show more |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 459703 | SCN1A | sodium voltage-gated channel alpha subunit 1 | 9598 | VGNC:14353 | OMA, EggNOG |
| Macaque | 704086 | SCN1A | sodium voltage-gated channel alpha subunit 1 | 9544 | Inparanoid, OMA | |
| Mouse | 20265 | Scn1a | sodium channel, voltage-gated, type I, alpha | 10090 | MGI:98246 | Inparanoid, OMA, EggNOG |
| Rat | 81574 | Scn1a | sodium voltage-gated channel alpha subunit 1 | 10116 | RGD:69364 | Inparanoid, OMA |
| Dog | 478775 | SCN1A | sodium voltage-gated channel alpha subunit 1 | 9615 | VGNC:45915 | Inparanoid, OMA |
| Horse | 100052059 | SCN1A | sodium voltage-gated channel alpha subunit 1 | 9796 | VGNC:22732 | Inparanoid, OMA |
| Cow | 529590 | SCN1A | sodium voltage-gated channel alpha subunit 1 | 9913 | VGNC:34345 | Inparanoid, OMA |
| Opossum | 100016606 | SCN1A | sodium voltage-gated channel alpha subunit 1 | 13616 | Inparanoid, OMA, EggNOG | |
| Chicken | 771555 | SCN1A | sodium voltage-gated channel alpha subunit 1 | 9031 | CGNC:56868 | Inparanoid, EggNOG |
| Xenopus | scn1a | sodium channel, voltage gated, type I alpha subunit [Source:Xenbase;Acc:XB-GENE-978019] | 8364 | OMA, EggNOG | ||
| Zebrafish | 559447 | scn1lab | sodium channel, voltage-gated, type I like, alpha b | 7955 | ZDB-GENE-060906-1 | Inparanoid, OMA, EggNOG |
Protein Classes
PANTHER Classes
protein / transporter / calcium channel / Sodium channel protein type 1 subunit alpha
protein / transporter / voltage-gated sodium channel / Sodium channel protein type 1 subunit alpha
protein / transporter / voltage-gated calcium channel / Sodium channel protein type 1 subunit alpha
protein / transporter / sodium channel / Sodium channel protein type 1 subunit alpha
protein / transporter / voltage-gated ion channel / Sodium channel protein type 1 subunit alpha
protein / transporter / calcium channel / Sodium channel protein type 1 subunit alpha
protein / transporter / voltage-gated sodium channel / Sodium channel protein type 1 subunit alpha
protein / transporter / voltage-gated calcium channel / Sodium channel protein type 1 subunit alpha
protein / transporter / sodium channel / Sodium channel protein type 1 subunit alpha
protein / transporter / voltage-gated ion channel / Sodium channel protein type 1 subunit alpha
DTO Classes
protein / Ion channel / Sodium channel family / Nav1.1/SCN1A subfamily / Sodium channel protein type 1 subunit alpha
protein / Ion channel / Sodium channel family / Nav1.1/SCN1A subfamily / Sodium channel protein type 1 subunit alpha
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Activity | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | species | Application | View Details |
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Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Disease Type | Mondoid |
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Pathway
| Data Source | Name | Explore more targets | Explore in Source |
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