SCN8A
| Description | Sodium channel protein type 8 subunit alpha |
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Gene and Protein Information
| Gene ID | 6334 |
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| Uniprot Accession IDs | B9VWG8 O95788 Q9NYX2 Q9UPB2 |
| Ensembl ID | ENSP00000346534 |
| Symbol | MED MED PN4 CIAT BFIS5 NaCh6 CERIII EIEE13 MYOCL2 Nav1.6 |
| Family | Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily. |
| Sequence | MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESKC Show more |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Macaque | 695972 | SCN8A | sodium voltage-gated channel alpha subunit 8 | 9544 | Inparanoid, OMA, EggNOG | |
| Mouse | 20273 | Scn8a | sodium channel, voltage-gated, type VIII, alpha | 10090 | MGI:103169 | Inparanoid, OMA, EggNOG |
| Rat | 29710 | Scn8a | sodium voltage-gated channel alpha subunit 8 | 10116 | RGD:3638 | Inparanoid, OMA, EggNOG |
| Dog | 477604 | SCN8A | sodium voltage-gated channel alpha subunit 8 | 9615 | VGNC:45923 | Inparanoid, OMA |
| Horse | 100052777 | SCN8A | sodium voltage-gated channel alpha subunit 8 | 9796 | VGNC:22742 | Inparanoid, OMA |
| Cow | 537277 | SCN8A | sodium voltage-gated channel alpha subunit 8 | 9913 | VGNC:34354 | Inparanoid, OMA |
| Anole lizard | 100556690 | scn8a | sodium voltage-gated channel alpha subunit 8 | 28377 | Inparanoid, OMA | |
| Xenopus | 549640 | scn8a | sodium channel, voltage gated, type VIII alpha subunit | 8364 | XB-GENE-1011299 | Inparanoid, OMA |
| Zebrafish | 58152 | scn8aa | sodium channel, voltage gated, type VIII, alpha subunit a | 7955 | ZDB-GENE-000828-1 | Inparanoid, OMA |
Protein Classes
PANTHER Classes
protein / transporter / calcium channel / Sodium channel protein type 8 subunit alpha
protein / transporter / voltage-gated sodium channel / Sodium channel protein type 8 subunit alpha
protein / transporter / voltage-gated calcium channel / Sodium channel protein type 8 subunit alpha
protein / transporter / sodium channel / Sodium channel protein type 8 subunit alpha
protein / transporter / voltage-gated ion channel / Sodium channel protein type 8 subunit alpha
protein / transporter / calcium channel / Sodium channel protein type 8 subunit alpha
protein / transporter / voltage-gated sodium channel / Sodium channel protein type 8 subunit alpha
protein / transporter / voltage-gated calcium channel / Sodium channel protein type 8 subunit alpha
protein / transporter / sodium channel / Sodium channel protein type 8 subunit alpha
protein / transporter / voltage-gated ion channel / Sodium channel protein type 8 subunit alpha
DTO Classes
protein / Ion channel / Sodium channel family / Nav1.6/SCN8A subfamily / Sodium channel protein type 8 subunit alpha
protein / Ion channel / Sodium channel family / Nav1.6/SCN8A subfamily / Sodium channel protein type 8 subunit alpha
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Activity | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | species | Application | View Details |
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Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Disease Type | Mondoid |
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Pathway
| Data Source | Name | Explore more targets | Explore in Source |
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