IARS

Description	Isoleucine--tRNA ligase, cytoplasmic

Gene and Protein Information

Gene ID	3376
Uniprot Accession IDs	A8KAE9 Q5TCD0 Q7Z3T4 Q9H588
Ensembl ID	ENSP00000364794
Symbol	IRS ILRS IARS1 ILERS GRIDHH PRO0785
Family	Belongs to the class-I aminoacyl-tRNA synthetase family.
Sequence	MLQQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATGGTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLPGPACAYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDETEIQNQTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLLLENPLGQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSVLPTTADF Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	465229	IARS	isoleucyl-tRNA synthetase	9598	VGNC:4761	OMA, EggNOG
Macaque	677705	IARS	isoleucyl-tRNA synthetase	9544		Inparanoid, OMA, EggNOG
Mouse	105148	Iars	isoleucine-tRNA synthetase	10090	MGI:2145219	Inparanoid, OMA, EggNOG
Rat	306804	Iars	isoleucyl-tRNA synthetase	10116	RGD:621022	Inparanoid, OMA, EggNOG
Dog	484216	IARS	isoleucyl-tRNA synthetase	9615	VGNC:41849	Inparanoid, OMA, EggNOG
Horse	100054721	IARS	isoleucyl-tRNA synthetase	9796	VGNC:18921	Inparanoid, OMA, EggNOG
Cow	509885	IARS	isoleucyl-tRNA synthetase	9913	VGNC:30018	Inparanoid, OMA, EggNOG
Pig	100624746	IARS	isoleucyl-tRNA synthetase	9823		OMA, EggNOG
Opossum	100029867	IARS	isoleucyl-tRNA synthetase	13616		Inparanoid, OMA, EggNOG
Platypus	100081997	IARS	isoleucyl-tRNA synthetase	9258		Inparanoid, OMA, EggNOG
Chicken	415957	IARS	isoleucyl-tRNA synthetase	9031	CGNC:3573	Inparanoid, OMA, EggNOG
Anole lizard	100554864	iars	isoleucyl-tRNA synthetase	28377		Inparanoid, OMA, EggNOG
Xenopus	100036668	iars	isoleucyl-tRNA synthetase	8364	XB-GENE-1001585	Inparanoid, OMA, EggNOG
Zebrafish	334393	iars	isoleucyl-tRNA synthetase	7955	ZDB-GENE-030131-6325	Inparanoid, OMA, EggNOG
C. elegans	177926	iars-1	Isoleucine--tRNA ligase, cytoplasmic	6239		Inparanoid, OMA, EggNOG
S.cerevisiae	852202	ILS1	isoleucine--tRNA ligase ILS1	4932	S000000172	Inparanoid, OMA, EggNOG

PANTHER Classes
protein / ligase / aminoacyl-tRNA synthetase / Isoleucine--tRNA ligase, cytoplasmic

DTO Classes
protein / Enzyme / Ligase / Aminoacyl-tRNA synthetase / Isoleucine--tRNA ligase, cytoplasmic

Name	Specification and purity	Expression system	Protein label	Activity	View Details

Name	Specifications	Species reactivity	species	Application	View Details

Name	Disease Type	Mondoid

Data Source	Name	Explore more targets	Explore in Source