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IARS

DescriptionIsoleucine--tRNA ligase, cytoplasmic

Gene and Protein Information

Gene ID3376
Uniprot Accession IDs A8KAE9 Q5TCD0 Q7Z3T4 Q9H588
Ensembl ID ENSP00000364794
Symbol IRS ILRS IARS1 ILERS GRIDHH PRO0785
FamilyBelongs to the class-I aminoacyl-tRNA synthetase family.
Sequence
MLQQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATGGTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLPGPACAYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDETEIQNQTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLLLENPLGQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSVLPTTADF
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp465229IARSisoleucyl-tRNA synthetase9598VGNC:4761OMA, EggNOG
Macaque677705IARSisoleucyl-tRNA synthetase9544Inparanoid, OMA, EggNOG
Mouse105148Iarsisoleucine-tRNA synthetase10090MGI:2145219Inparanoid, OMA, EggNOG
Rat306804Iarsisoleucyl-tRNA synthetase10116RGD:621022Inparanoid, OMA, EggNOG
Dog484216IARSisoleucyl-tRNA synthetase9615VGNC:41849Inparanoid, OMA, EggNOG
Horse100054721IARSisoleucyl-tRNA synthetase9796VGNC:18921Inparanoid, OMA, EggNOG
Cow509885IARSisoleucyl-tRNA synthetase9913VGNC:30018Inparanoid, OMA, EggNOG
Pig100624746IARSisoleucyl-tRNA synthetase9823OMA, EggNOG
Opossum100029867IARSisoleucyl-tRNA synthetase13616Inparanoid, OMA, EggNOG
Platypus100081997IARSisoleucyl-tRNA synthetase9258Inparanoid, OMA, EggNOG
Chicken415957IARSisoleucyl-tRNA synthetase9031CGNC:3573Inparanoid, OMA, EggNOG
Anole lizard100554864iarsisoleucyl-tRNA synthetase28377Inparanoid, OMA, EggNOG
Xenopus100036668iarsisoleucyl-tRNA synthetase8364XB-GENE-1001585Inparanoid, OMA, EggNOG
Zebrafish334393iarsisoleucyl-tRNA synthetase7955ZDB-GENE-030131-6325Inparanoid, OMA, EggNOG
C. elegans177926iars-1Isoleucine--tRNA ligase, cytoplasmic6239Inparanoid, OMA, EggNOG
S.cerevisiae852202ILS1isoleucine--tRNA ligase ILS14932S000000172Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    ligase    /    aminoacyl-tRNA synthetase    /    Isoleucine--tRNA ligase, cytoplasmic
DTO Classes
protein    /    Enzyme    /    Ligase    /    Aminoacyl-tRNA synthetase    /    Isoleucine--tRNA ligase, cytoplasmic

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityspeciesApplicationView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDisease TypeMondoid

      Pathway

      Data SourceNameExplore more targetsExplore in Source
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