WRN

Description	Werner syndrome ATP-dependent helicase

Gene and Protein Information

Gene ID	7486
Uniprot Accession IDs	A1KYY9
Ensembl ID	ENSP00000298139
Symbol	RECQ3 RECQL2 RECQ3 RECQL2 RECQL3
Family	Belongs to the helicase family. RecQ subfamily.
Sequence	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	472732	WRN	Werner syndrome RecQ like helicase	9598	VGNC:7604	OMA, EggNOG
Macaque	695678	WRN	Werner syndrome RecQ like helicase	9544		Inparanoid, OMA, EggNOG
Mouse	22427	Wrn	Werner syndrome RecQ like helicase	10090	MGI:109635	Inparanoid, OMA, EggNOG
Rat	290805	Wrn	Werner syndrome RecQ like helicase	10116	RGD:1564788	Inparanoid, OMA, EggNOG
Dog	493997	WRN	Werner syndrome RecQ like helicase	9615		Inparanoid, OMA, EggNOG
Horse	100062021	WRN	Werner syndrome RecQ like helicase	9796		Inparanoid, OMA, EggNOG
Cow	505061	WRN	Werner syndrome RecQ like helicase	9913		Inparanoid, OMA, EggNOG
Pig	100512139	WRN	Werner syndrome RecQ like helicase	9823		OMA, EggNOG
Opossum	100019443	WRN	Werner syndrome RecQ like helicase	13616		Inparanoid, OMA, EggNOG
Platypus		WRN	Werner syndrome RecQ like helicase [Source:HGNC Symbol;Acc:HGNC:12791]	9258		OMA, EggNOG
Anole lizard	100561844	wrn	Werner syndrome RecQ like helicase	28377		Inparanoid, OMA, EggNOG
Xenopus	734043	wrn	Werner syndrome, RecQ helicase-like	8364	XB-GENE-992875	Inparanoid, OMA, EggNOG
Zebrafish	569495	wrn	Werner syndrome	7955	ZDB-GENE-070702-2	Inparanoid, OMA
C. elegans	174081	wrn-1	Probable Werner syndrome ATP-dependent helicase homolog 1	6239		Inparanoid, EggNOG

Protein Classes

PANTHER Classes
protein    /    nucleic acid binding    /    DNA binding protein    /    Werner syndrome ATP-dependent helicase
protein    /    nucleic acid binding    /    DNA helicase    /    Werner syndrome ATP-dependent helicase
protein    /    nucleic acid binding    /    helicase    /    Werner syndrome ATP-dependent helicase

DTO Classes
protein / Enzyme / Helicase / DNA helicase / Werner syndrome ATP-dependent helicase

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Activity	View Details

Associated Antibodies

Name	Specifications	Species reactivity	species	Application	View Details

Related active small molecules

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name	Disease Type	Mondoid

Pathway

Data Source	Name	Explore more targets	Explore in Source