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TBXAS1

DescriptionThromboxane-A synthase

Gene and Protein Information

Gene ID6916
Uniprot Accession IDs P24557 B4DJG6 E7EMU9 E7EP08 E7ESB5 O14987 Q16843 Q16844 Q8IUN1 Q96CN2 Q9GZW4 Q9HD77 Q9HD78 Q9HD79 Q9HD80 Q9HD81 Q9HD82 Q9HD83 Q9HD84 TXA synthase
Ensembl ID ENSP00000389414
Symbol CYP5 CYP5A1 TS TXS CYP5 THAS TXAS CYP5A1 GHOSAL BDPLT14
FamilyBelongs to the cytochrome P450 family.
Sequence
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp463774TBXAS1thromboxane A synthase 19598VGNC:4530OMA, EggNOG
Macaque711748TBXAS1thromboxane A synthase 19544Inparanoid, OMA, EggNOG
Mouse21391Tbxas1thromboxane A synthase 1, platelet10090MGI:98497Inparanoid, OMA, EggNOG
Rat24886Tbxas1thromboxane A synthase 110116RGD:3826Inparanoid, OMA, EggNOG
Dog482771TBXAS1thromboxane A synthase 19615VGNC:47178Inparanoid, OMA, EggNOG
Horse100066198TBXAS1thromboxane A synthase 19796VGNC:23937Inparanoid, OMA, EggNOG
Cow509326TBXAS1thromboxane A synthase 19913VGNC:35674Inparanoid, OMA, EggNOG
Pig397112TBXAS1thromboxane A synthase 19823Inparanoid, OMA, EggNOG
Opossum100023523TBXAS1thromboxane A synthase 113616Inparanoid, OMA, EggNOG
Platypus100087744TBXAS1thromboxane A synthase 19258Inparanoid, OMA, EggNOG
Chicken418101TBXAS1thromboxane A synthase 19031CGNC:9697Inparanoid, OMA, EggNOG
Zebrafish792041tbxas1thromboxane A synthase 1 (platelet)7955ZDB-GENE-030131-8805Inparanoid, OMA, EggNOG

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

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      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Cargill, M M and 17 more authors. 1999-07 Characterization of single-nucleotide polymorphisms in coding regions of human genes. [PMID:10391209]
      2.Halushka, M K MK and 8 more authors. 1999-07 Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. [PMID:10391210]
      3.Wang, L H LH, Tsai, A L AL and Hsu, P Y PY. 2001-05-04 Substrate binding is the rate-limiting step in thromboxane synthase catalysis. [PMID:11297515]
      4.Suzuki, Y Y and 14 more authors. 2001-05 Identification and characterization of the potential promoter regions of 1031 kinds of human genes. [PMID:11337467]
      5.Ueno, N N and 6 more authors. 2001-09-14 Coupling between cyclooxygenase, terminal prostanoid synthase, and phospholipase A2. [PMID:11418589]
      6.Chevalier, D D and 8 more authors. 2001-01 Identification of genetic variants in the human thromboxane synthase gene (CYP5A1). [PMID:11465543]
      7.Pradono, Prasenohadi P and 7 more authors. 2002-01-01 Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth. [PMID:11782360]
      8.Wang, Lee-Ho LH and Kulmacz, Richard J RJ. 2002-08 Thromboxane synthase: structure and function of protein and gene. [PMID:12432933]
      9.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      10.Saito, Susumu S and 6 more authors. 2003 Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. [PMID:12721789]