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TOP1

DescriptionDNA topoisomerase 1

Gene and Protein Information

Gene ID7150
Uniprot Accession IDs A8KA78 E1P5W3 O43256 Q12855 Q12856 Q15610 Q5TFY3 Q9UJN0
Ensembl ID ENSP00000354522
Symbol TOPI
FamilyBelongs to the type IB topoisomerase family.
Sequence
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEPEDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKDKDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp458252TOP1DNA topoisomerase I9598VGNC:10014OMA, EggNOG
Macaque697300TOP1DNA topoisomerase I9544Inparanoid, OMA, EggNOG
Mouse21969Top1topoisomerase (DNA) I10090MGI:98788Inparanoid, OMA, EggNOG
Rat64550Top1DNA topoisomerase I10116RGD:621246Inparanoid, OMA
Dog477229TOP1DNA topoisomerase I9615VGNC:49631Inparanoid, OMA, EggNOG
Horse100070532TOP1DNA topoisomerase I9796VGNC:50515Inparanoid, OMA, EggNOG
Cow534799TOP1DNA topoisomerase I9913VGNC:49136Inparanoid, OMA, EggNOG
Pig100518587TOP1DNA topoisomerase I9823Inparanoid, OMA, EggNOG
Opossum100032710TOP1DNA topoisomerase I13616Inparanoid, EggNOG
Platypus100078817TOP1DNA topoisomerase I9258Inparanoid, OMA, EggNOG
Chicken396004TOP1topoisomerase (DNA) I9031CGNC:2691Inparanoid, OMA, EggNOG
Anole lizard100559150top1DNA topoisomerase I28377Inparanoid, OMA, EggNOG
Xenopus100496521top1.1DNA topoisomerase I, gene 18364XB-GENE-950002Inparanoid, EggNOG
Zebrafish553496top1lDNA topoisomerase I, like7955ZDB-GENE-060616-217Inparanoid, OMA, EggNOG
Fruitfly32458Top1Topoisomerase 17227FBgn0004924Inparanoid, EggNOG
S.cerevisiae854156TOP1DNA topoisomerase 14932S000005366OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    nucleic acid binding    /    DNA topoisomerase    /    DNA topoisomerase 1
DTO Classes
protein    /    Enzyme    /    Isomerase    /    DNA topoisomerase    /    DNA topoisomerase 1

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details
Recombinant Human IGSF4A/SynCAM1 ProteinHEK293C-His
Out of Stock
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Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
Recombinant Topoisomerase I AntibodyHuman,Mouse,Rat
  • IF/ICC
  • IHC
  • WB
Out of Stock
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Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      acute quadriplegic myopathy1255Expression AtlasMONDO:0005336
      astrocytoma3773Expression AtlasMONDO:0021636
      colon cancer1587Expression AtlasMONDO:0021063
      juvenile dermatomyositis1263Expression AtlasMONDO:0008054
      psoriasis6696Expression AtlasMONDO:0005083
      Drug-Related Side Effects and Adverse Reactions0CTD
      Neoplasms162CTDMONDO:0004992
      Malignant neoplasm of breast0DisGeNET
      Malignant Neoplasms162DisGeNETMONDO:0004992
      Drug toxicity0DisGeNET

      Bibliography

      1.Haluska, P P and 6 more authors. 1999-06-15 Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein. [PMID:10352183]
      2.Gobert, C C, Skladanowski, A A and Larsen, A K AK. 1999-08-31 The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53. [PMID:10468612]
      3.Redinbo, M R MR, Stewart, L L, Champoux, J J JJ and Hol, W G WG. 1999-09-24 Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures. [PMID:10497031]
      4.Ahuja, H G HG, Felix, C A CA and Aplan, P D PD. 1999-11-01 The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion. [PMID:10556215]
      5.Mao, Y Y, Sun, M M, Desai, S D SD and Liu, L F LF. 2000-04-11 SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage. [PMID:10759568]
      6.Suzuki, T T, Uchida-Toita, M M, Andoh, T T and Yoshida, M M. 2000-05-10 HTLV-1 tax oncoprotein binds to DNA topoisomerase I and inhibits its catalytic activity. [PMID:10792988]
      7.Redinbo, M R MR, Champoux, J J JJ and Hol, W G WG. 2000-06-13 Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA. [PMID:10841763]
      8.Edwards, T K TK and 7 more authors. 2000-11-17 Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I. [PMID:10967121]
      9.Mo, Y Y YY, Wang, C C and Beck, W T WT. 2000-12-29 A novel nuclear localization signal in human DNA topoisomerase I. [PMID:11016921]
      10.Takasaki, Y Y and 8 more authors. 2001-04-01 Reactivity of anti-proliferating cell nuclear antigen (PCNA) murine monoclonal antibodies and human autoantibodies to the PCNA multiprotein complexes involved in cell proliferation. [PMID:11254741]