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TOP1
| Description | DNA topoisomerase 1 |
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Gene and Protein Information
| Gene ID | 7150 |
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| Uniprot Accession IDs | A8KA78 E1P5W3 O43256 Q12855 Q12856 Q15610 Q5TFY3 Q9UJN0 |
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| Ensembl ID | ENSP00000354522 |
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| Symbol | TOPI |
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| Family | Belongs to the type IB topoisomerase family. |
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| Sequence | MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEPEDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKDKDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF Show more |
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Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
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| Chimp | 458252 | TOP1 | DNA topoisomerase I | 9598 | VGNC:10014 | OMA, EggNOG |
| Macaque | 697300 | TOP1 | DNA topoisomerase I | 9544 | | Inparanoid, OMA, EggNOG |
| Mouse | 21969 | Top1 | topoisomerase (DNA) I | 10090 | MGI:98788 | Inparanoid, OMA, EggNOG |
| Rat | 64550 | Top1 | DNA topoisomerase I | 10116 | RGD:621246 | Inparanoid, OMA |
| Dog | 477229 | TOP1 | DNA topoisomerase I | 9615 | VGNC:49631 | Inparanoid, OMA, EggNOG |
| Horse | 100070532 | TOP1 | DNA topoisomerase I | 9796 | VGNC:50515 | Inparanoid, OMA, EggNOG |
| Cow | 534799 | TOP1 | DNA topoisomerase I | 9913 | VGNC:49136 | Inparanoid, OMA, EggNOG |
| Pig | 100518587 | TOP1 | DNA topoisomerase I | 9823 | | Inparanoid, OMA, EggNOG |
| Opossum | 100032710 | TOP1 | DNA topoisomerase I | 13616 | | Inparanoid, EggNOG |
| Platypus | 100078817 | TOP1 | DNA topoisomerase I | 9258 | | Inparanoid, OMA, EggNOG |
| Chicken | 396004 | TOP1 | topoisomerase (DNA) I | 9031 | CGNC:2691 | Inparanoid, OMA, EggNOG |
| Anole lizard | 100559150 | top1 | DNA topoisomerase I | 28377 | | Inparanoid, OMA, EggNOG |
| Xenopus | 100496521 | top1.1 | DNA topoisomerase I, gene 1 | 8364 | XB-GENE-950002 | Inparanoid, EggNOG |
| Zebrafish | 553496 | top1l | DNA topoisomerase I, like | 7955 | ZDB-GENE-060616-217 | Inparanoid, OMA, EggNOG |
| Fruitfly | 32458 | Top1 | Topoisomerase 1 | 7227 | FBgn0004924 | Inparanoid, EggNOG |
| S.cerevisiae | 854156 | TOP1 | DNA topoisomerase 1 | 4932 | S000005366 | OMA, EggNOG |
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Activity | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | species | Application | View Details |
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Associated Approved Drugs
Associated Active Ligands
Pathway
| Data Source | Name | Explore more targets | Explore in Source |
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