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TOP2A
| Description | DNA topoisomerase 2-alpha |
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Gene and Protein Information
| Gene ID | 7153 |
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| Uniprot Accession IDs | B2RTS1 Q71UN1 Q71UQ5 Q9HB24 Q9HB25 Q9HB26 Q9UP44 Q9UQP9 |
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| Ensembl ID | ENSP00000411532 |
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| Symbol | TOP2 TOP2 TP2A |
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| Family | Belongs to the type II topoisomerase family. |
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| Sequence | MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF Show more |
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Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
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| Chimp | 454651 | TOP2A | DNA topoisomerase II alpha | 9598 | VGNC:9732 | Inparanoid, OMA, EggNOG |
| Mouse | 21973 | Top2a | topoisomerase (DNA) II alpha | 10090 | MGI:98790 | Inparanoid, OMA |
| Rat | 360243 | Top2a | DNA topoisomerase II alpha | 10116 | RGD:62048 | Inparanoid, OMA |
| Dog | 480525 | TOP2A | DNA topoisomerase II alpha | 9615 | VGNC:49098 | Inparanoid, OMA, EggNOG |
| Horse | 100054229 | TOP2A | DNA topoisomerase II alpha | 9796 | VGNC:50516 | Inparanoid, OMA, EggNOG |
| Cow | 787696 | TOP2A | DNA topoisomerase II alpha | 9913 | VGNC:49583 | Inparanoid, OMA, EggNOG |
| Pig | 396917 | TOP2A | DNA topoisomerase II alpha | 9823 | | Inparanoid, OMA, EggNOG |
| Opossum | 100016027 | TOP2A | DNA topoisomerase II alpha | 13616 | | Inparanoid, OMA, EggNOG |
| Platypus | 100090593 | TOP2A | DNA topoisomerase II alpha | 9258 | | Inparanoid, OMA, EggNOG |
| Chicken | 395570 | TOP2A | topoisomerase (DNA) II alpha | 9031 | CGNC:49380 | Inparanoid, OMA |
| Anole lizard | 100562686 | top2a | DNA topoisomerase II alpha | 28377 | | Inparanoid, OMA |
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Activity | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | species | Application | View Details |
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Associated Approved Drugs
Associated Active Ligands
Pathway
| Data Source | Name | Explore more targets | Explore in Source |
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