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TGFB3

DescriptionTransforming growth factor beta-3 proprotein

Gene and Protein Information

Gene ID7043
Uniprot Accession IDs P10600 Q8WV88
Ensembl ID ENSP00000238682
Symbol ARVD LDS5 RNHF ARVD1 TGF-beta3
FamilyBelongs to the TGF-beta family.
Sequence
MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp453054TGFB3transforming growth factor beta 39598VGNC:3304OMA, EggNOG
Macaque703239TGFB3transforming growth factor beta 39544Inparanoid, OMA, EggNOG
Mouse21809Tgfb3transforming growth factor, beta 310090MGI:98727Inparanoid, OMA, EggNOG
Rat25717Tgfb3transforming growth factor, beta 310116RGD:3851Inparanoid, OMA, EggNOG
Dog490796TGFB3transforming growth factor beta 39615VGNC:47310Inparanoid, OMA, EggNOG
Horse100051765TGFB3transforming growth factor beta 39796VGNC:24054Inparanoid, OMA, EggNOG
Cow538957TGFB3transforming growth factor beta 39913VGNC:35803Inparanoid, OMA, EggNOG
Pig397400TGFB3transforming growth factor beta 39823Inparanoid, OMA, EggNOG
Opossum100017937TGFB3transforming growth factor beta 313616Inparanoid, EggNOG
Chicken396438TGFB3transforming growth factor beta 39031CGNC:7874Inparanoid, OMA, EggNOG
Anole lizard100551709tgfb3transforming growth factor beta 328377OMA, EggNOG
Zebrafish369195tgfb3transforming growth factor, beta 37955ZDB-GENE-030723-4Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    signaling molecule    /    growth factor    /    Transforming growth factor beta-3
DTO Classes
protein    /    Signaling    /    Growth factor    /    Transforming growth factor beta-3

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

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      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Lux, A A, Attisano, L L and Marchuk, D A DA. 1999-04-09 Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1. [PMID:10187774]
      2.Mori, T T and 8 more authors. 1999-10 Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model. [PMID:10457363]
      3.Saharinen, J J and Keski-Oja, J J. 2000-08 Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta. [PMID:10930463]
      4.Rotzer, D D and 5 more authors. 2001-02-01 Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor. [PMID:11157754]
      5.Lee, B S BS and Nowak, R A RA. 2001-02 Human leiomyoma smooth muscle cells show increased expression of transforming growth factor-beta 3 (TGF beta 3) and altered responses to the antiproliferative effects of TGF beta. [PMID:11158066]
      6.Bellone, G G and 12 more authors. 2001-01 Differential expression of transforming growth factors-beta1, -beta2 and -beta3 in human colon carcinoma. [PMID:11166150]
      7.Kinnman, N N, Andersson, U U and Hultcrantz, R R. 2000-12 In situ expression of transforming growth factor-beta1-3, latent transforming growth factor-beta binding protein and tumor necrosis factor-alpha in liver tissue from patients with chronic hepatitis C. [PMID:11199370]
      8.Hering, S S and 7 more authors. 2001 Analysis of TGFbeta3 gene expression and protein levels in human bone and serum. [PMID:11341298]
      9. and Jeziorska, M M. 2001 Transforming growth factor-betas and CD105 expression in calcification and bone formation in human atherosclerotic lesions. [PMID:11374028]
      10.De Crescenzo, G G, Grothe, S S, Zwaagstra, J J, Tsang, M M and O'Connor-McCourt, M D MD. 2001-08-10 Real-time monitoring of the interactions of transforming growth factor-beta (TGF-beta ) isoforms with latency-associated protein and the ectodomains of the TGF-beta type II and III receptors reveals different kinetic models and stoichiometries of binding. [PMID:11382746]