SIRT1
| Description | NAD-dependent protein deacetylase sirtuin-1 |
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Gene and Protein Information
| Gene ID | 23411 |
|---|---|
| Uniprot Accession IDs | Q2XNF6 Q5JVQ0 Q9GZR9 Q9Y6F0 hSIRT1 |
| Ensembl ID | ENSP00000212015 |
| Symbol | SIR2L1 SIR2 SIR2L1 SIR2alpha |
| Family | Belongs to the sirtuin family. Class I subfamily. |
| Sequence | MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS Show more |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 107966703 | SIRT1 | sirtuin 1 | 9598 | VGNC:12502 | OMA, EggNOG |
| Macaque | 695682 | SIRT1 | sirtuin 1 | 9544 | OMA, EggNOG | |
| Mouse | 93759 | Sirt1 | sirtuin 1 | 10090 | MGI:2135607 | Inparanoid, OMA, EggNOG |
| Dog | 489012 | SIRT1 | sirtuin 1 | 9615 | VGNC:46183 | Inparanoid, OMA, EggNOG |
| Horse | 100072571 | SIRT1 | sirtuin 1 | 9796 | VGNC:51676 | Inparanoid, OMA, EggNOG |
| Cow | 613629 | SIRT1 | sirtuin 1 | 9913 | VGNC:34630 | Inparanoid, OMA, EggNOG |
| Pig | 751859 | SIRT1 | sirtuin 1 | 9823 | Inparanoid, OMA, EggNOG | |
| Opossum | 100015574 | SIRT1 | sirtuin 1 | 13616 | Inparanoid, EggNOG | |
| Chicken | 423646 | SIRT1 | sirtuin 1 | 9031 | CGNC:52016 | Inparanoid, OMA, EggNOG |
| Anole lizard | 100564010 | sirt1 | sirtuin 1 | 28377 | Inparanoid, OMA, EggNOG | |
| Xenopus | 100145679 | sirt1 | sirtuin 1 | 8364 | XB-GENE-989003 | Inparanoid, OMA, EggNOG |
| Zebrafish | 797132 | sirt1 | sirtuin 1 | 7955 | ZDB-GENE-070801-2 | Inparanoid, OMA, EggNOG |
| Fruitfly | 34708 | Sirt1 | Sirtuin 1 | 7227 | FBgn0024291 | Inparanoid, EggNOG |
Protein Classes
PANTHER Classes
protein / hydrolase / deacetylase / NAD-dependent protein deacetylase sirtuin-1
protein / hydrolase / chromatin/chromatin-binding protein / NAD-dependent protein deacetylase sirtuin-1
protein / hydrolase / deacetylase / NAD-dependent protein deacetylase sirtuin-1
protein / hydrolase / chromatin/chromatin-binding protein / NAD-dependent protein deacetylase sirtuin-1
DTO Classes
protein / Epigenetic regulator / Eraser / Histone deacetylase / HDAC class III / NAD-dependent protein deacetylase sirtuin-1
protein / Epigenetic regulator / Eraser / Histone deacetylase / HDAC class III / NAD-dependent protein deacetylase sirtuin-1
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Activity | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | species | Application | View Details |
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Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Disease Type | Mondoid |
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Pathway
| Data Source | Name | Explore more targets | Explore in Source |
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