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ERBB2

DescriptionReceptor tyrosine-protein kinase erbB-2

Gene and Protein Information

Gene ID2064
Uniprot Accession IDs P04626 B2RZG3 B4DHN3 Q14256 Q6LDV1 Q9UMK4 X5D2V5
Ensembl ID ENSP00000269571
Symbol HER2 MLN19 NEU NGL NEU NGL HER2 TKR1 CD340 HER-2 MLN 19 HER-2/neu
FamilyBelongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Sequence
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp454636ERBB2erb-b2 receptor tyrosine kinase 29598VGNC:9276OMA, EggNOG
Macaque697573ERBB2erb-b2 receptor tyrosine kinase 29544Inparanoid, OMA, EggNOG
Mouse13866Erbb2erb-b2 receptor tyrosine kinase 210090MGI:95410Inparanoid, OMA, EggNOG
Rat24337Erbb2erb-b2 receptor tyrosine kinase 210116RGD:2561Inparanoid, OMA, EggNOG
Dog403883ERBB2erb-b2 receptor tyrosine kinase 29615VGNC:40436Inparanoid, OMA, EggNOG
Horse100054739ERBB2erb-b2 receptor tyrosine kinase 29796VGNC:17649Inparanoid, OMA, EggNOG
Cow505709ERBB2erb-b2 receptor tyrosine kinase 29913VGNC:28563OMA, EggNOG
Pig100516641ERBB2erb-b2 receptor tyrosine kinase 29823OMA, EggNOG
Opossum100017172ERBB2erb-b2 receptor tyrosine kinase 213616Inparanoid, OMA, EggNOG
Anole lizard100565910erbb2erb-b2 receptor tyrosine kinase 228377Inparanoid, OMA
Zebrafish386966erbb2erb-b2 receptor tyrosine kinase 27955ZDB-GENE-031118-121Inparanoid, OMA

Protein Classes

DTO Classes
protein    /    Kinase    /    Protein kinase    /    TK group    /    EGFR family    /    Receptor tyrosine-protein kinase erbb-2

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

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      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Child, S J SJ, Miller, M K MK and Geballe, A P AP. 1999-01 Cell type-dependent and -independent control of HER-2/neu translation. [PMID:10216954]
      2.Nezu, M M and 10 more authors. 1999-05-19 Identification of a novel promoter and exons of the c-ERBB-2 gene. [PMID:10329415]
      3.Gulliford, T T, Ouyang, X X and Epstein, R J RJ. 1999-04 Intensification of growth factor receptor signalling by phorbol treatment of ligand-primed cells implies a dimer-stabilizing effect of protein kinase C-dependent juxtamembrane domain phosphorylation. [PMID:10372802]
      4.Child, S J SJ, Miller, M K MK and Geballe, A P AP. 1999-08-20 Translational control by an upstream open reading frame in the HER-2/neu transcript. [PMID:10446211]
      5.Doherty, J K JK, Bond, C C, Jardim, A A, Adelman, J P JP and Clinton, G M GM. 1999-09-14 The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor. [PMID:10485918]
      6.Fernandes, A M AM, Hamburger, A W AW and Gerwin, B I BI. 1999-12 Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity. [PMID:10572067]
      7.Kuhns, J J JJ, Batalia, M A MA, Yan, S S and Collins, E J EJ. 1999-12-17 Poor binding of a HER-2/neu epitope (GP2) to HLA-A2.1 is due to a lack of interactions with the center of the peptide. [PMID:10593938]
      8.Zrihan-Licht, S S and 7 more authors. 2000-03-02 RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion. [PMID:10713673]
      9.Vartanian, T T, Goodearl, A A, Lefebvre, S S, Park, S K SK and Fischbach, G G. 2000-05-10 Neuregulin induces the rapid association of focal adhesion kinase with the erbB2-erbB3 receptor complex in schwann cells. [PMID:10799311]
      10.Arcaro, A A and 5 more authors. 2000-06 Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. [PMID:10805725]