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Tariquidar dihydrochloride - ≥98%, high purity , CAS No.1992047-62-7
Potent P-glycoprotein (P-gp) inhibitor
Basic Description Synonyms N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarbxamide dihydrochloride Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Potent P-glycoprotein (P-gp) inhibitor (IC50= 5.1 nM). Reverses drug resistance in multiple MDR cell lines. Acts as a substrate for breast cancer resistance protein (BCRP) at low concentrations and acts as an inhibitor of BCRP when used at >100 nM concent Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Names and Identifiers IUPAC Name N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide;dihydrochloride INCHI InChI=1S/C38H38N4O6.2ClH/c1-45-33-18-25-14-16-42(23-28(25)19-34(33)46-2)15-13-24-9-11-29(12-10-24)40-38(44)30-20-35(47-3)36(48-4)21-32(30)41-37(43)27-17-26-7-5-6-8-31(26)39-22-27;;/h5-12,17-22H,13-16,23H2,1-4H3,(H,40,44)(H,41,43);2*1H InChi Key ZJCJRGRTDKIFJJ-UHFFFAOYSA-N Canonical SMILES COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC(=O)C4=CC(=C(C=C4NC(=O)C5=CC6=CC=CC=C6N=C5)OC)OC)OC.Cl.Cl PubChem CID 121513890 Molecular Weight 719.66
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 71.97, Max Conc. mM: 100
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H2427205
