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Tasquinimod - 98%, high purity , CAS No.254964-60-8, Allosteric modulator of histone deacetylase 4

  • Moligand™
  • ≥98%
Item Number
T125086
Grouped product items
SKUSizeAvailabilityPrice Qty
T125086-5mg
5mg
In stock
$89.90
T125086-10mg
10mg
In stock
$205.90
T125086-25mg
25mg
In stock
$219.90
T125086-50mg
50mg
In stock
$329.90
T125086-100mg
100mg
In stock
$499.90
T125086-250mg
250mg
In stock
$899.90
T125086-500mg
500mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,299.90
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High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic

View related series
histone deacetylase 4 Allosteric modulator

Basic Description

SynonymsTasquinimod|254964-60-8|ABR-215050|Tasquinimod [INN]|4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]quinoline-3-carboxamide|4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-(4-(trifluoromethyl)-phenyl)-1,2-dihydroquinoline-3-carboxamide|756U0
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsHigh affinity negative allosteric modulator of HDAC4 (Kd= 10 - 30 nM). Binds the regulatory Zn2+binding domain of HDAC4. Suppresses hypoxia-induced decrease in histone acetylation in human prostate cancer cellsin vitro. Also binds S100A9. Antiangiogenic.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of histone deacetylase 4

Associated Targets

HDAC4 Tclin Histone deacetylase 4 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488201697
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488201697
IUPAC Name 4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]quinoline-3-carboxamide
INCHI InChI=1S/C20H17F3N2O4/c1-24(12-9-7-11(8-10-12)20(21,22)23)18(27)16-17(26)15-13(25(2)19(16)28)5-4-6-14(15)29-3/h4-10,26H,1-3H3
InChi Key ONDYALNGTUAJDX-UHFFFAOYSA-N
Canonical SMILES CN1C2=C(C(=CC=C2)OC)C(=C(C1=O)C(=O)N(C)C3=CC=C(C=C3)C(F)(F)F)O
Isomeric SMILES CN1C2=C(C(=CC=C2)OC)C(=C(C1=O)C(=O)N(C)C3=CC=C(C=C3)C(F)(F)F)O
PubChem CID 54682876
Molecular Weight 406.36

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Certificate of Analysis(COA)

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17 results found

Lot NumberCertificate TypeDateItem
K2321373Certificate of AnalysisNov 09, 2023 T125086
K2321372Certificate of AnalysisNov 09, 2023 T125086
K2321370Certificate of AnalysisNov 09, 2023 T125086
D2317433Certificate of AnalysisMar 08, 2023 T125086
J2331140Certificate of AnalysisMar 08, 2023 T125086
D2317437Certificate of AnalysisMar 08, 2023 T125086
D2317436Certificate of AnalysisMar 08, 2023 T125086
D2317435Certificate of AnalysisMar 08, 2023 T125086
D2317434Certificate of AnalysisMar 08, 2023 T125086
D2317375Certificate of AnalysisMar 08, 2023 T125086
D2317399Certificate of AnalysisMar 08, 2023 T125086
D2317398Certificate of AnalysisMar 08, 2023 T125086
D2317396Certificate of AnalysisMar 08, 2023 T125086
D2317390Certificate of AnalysisMar 08, 2023 T125086
D2317385Certificate of AnalysisMar 08, 2023 T125086
D2317381Certificate of AnalysisMar 08, 2023 T125086
D2317380Certificate of AnalysisMar 08, 2023 T125086

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 40.64, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 8.13, Max Conc. mM: 20

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. Tasquinimod - 10mM in DMSO, used for , CAS No. 254964-60-8, by Aladdin Scientific
    Tasquinimod

    Starting at $241.90

References

1. Isaacs JT, Antony L, Dalrymple SL, Brennen WN, Gerber S, Hammers H, Wissing M, Kachhap S, Luo J, Xing L et al..  (2013)  Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment..  Cancer Res,  73  (4): (1386-99).  [PMID:23149916]

Solution Calculators

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