Tasquinimod - 10mM in DMSO, high purity , CAS No.254964-60-8

Item Number

T422885

Grouped product items
SKU	Size	Availability	Price	Qty
T422885-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$241.90

High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic

Basic Description

Synonyms	Tasquinimod\|254964-60-8\|ABR-215050\|Tasquinimod [INN]\|4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]quinoline-3-carboxamide\|4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-(4-(trifluoromethyl)-phenyl)-1,2-dihydroquinoline-3-carboxamide\|756U0
Specifications & Purity	Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms	High affinity negative allosteric modulator of HDAC4 (Kd= 10 - 30 nM). Binds the regulatory Zn2+binding domain of HDAC4. Suppresses hypoxia-induced decrease in histone acetylation in human prostate cancer cellsin vitro. Also binds S100A9. Antiangiogenic.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]quinoline-3-carboxamide
INCHI	InChI=1S/C20H17F3N2O4/c1-24(12-9-7-11(8-10-12)20(21,22)23)18(27)16-17(26)15-13(25(2)19(16)28)5-4-6-14(15)29-3/h4-10,26H,1-3H3
InChi Key	ONDYALNGTUAJDX-UHFFFAOYSA-N
Canonical SMILES	CN1C2=C(C(=CC=C2)OC)C(=C(C1=O)C(=O)N(C)C3=CC=C(C=C3)C(F)(F)F)O
Isomeric SMILES	CN1C2=C(C(=CC=C2)OC)C(=C(C1=O)C(=O)N(C)C3=CC=C(C=C3)C(F)(F)F)O
PubChem CID	54682876
Molecular Weight	406.36

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Basic Description