| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| T651364-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $250.90 |
| Specifications & Purity | ≥95.0% |
|---|---|
| Storage Temp | Store at -20°C,Argon charged,Desiccated |
| Shipped In | Ice chest + Ice pads |
| Product Description | Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite , is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC 50 of 40 μM In Vitro T-βMCA sodium inhibits FXR reporter activity in the CRC cell line HT29 (EC 50 ~10 μM). T-βMCA sodium dose-dependently increases WNT signaling in HT29 and HCT116 cells. T-βMCA sodium induces proliferation and DNA damage in Lgr5 + cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression. T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: APCmin/+ miceDosage: 400 mg/kg Administration: Oral gavage; twice a week; for 6 weeks Result: Markedly decreased intestinal integrity and accelerated tumor growth in the intestine and colon. Form:Solid IC50& Target:IC50: 40 μM (FXR) |
| IUPAC Name | sodium;2-[[(4R)-4-[(3R,5R,6S,7R,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonate |
|---|---|
| INCHI | InChI=1S/C26H45NO7S.Na/c1-15(4-7-21(29)27-12-13-35(32,33)34)17-5-6-18-22-19(9-11-25(17,18)2)26(3)10-8-16(28)14-20(26)23(30)24(22)31;/h15-20,22-24,28,30-31H,4-14H2,1-3H3,(H,27,29)(H,32,33,34);/q;+1/p-1/t15-,16-,17-,18+,19+,20+,22+,23+,24-,25-,26-;/m1./s1 |
| InChi Key | NYXROOLWUZIWRB-GPHZYVDLSA-M |
| Canonical SMILES | CC(CCC(=O)NCCS(=O)(=O)[O-])C1CCC2C1(CCC3C2C(C(C4C3(CCC(C4)O)C)O)O)C.[Na+] |
| PubChem CID | 132285209 |
| Molecular Weight | 537.68 |
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| Solubility | DMSO : 10 mg/mL (18.60 mM; Need ultrasonic and warming) |
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