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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T287927-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $999.90 | |
T287927-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,399.90 | |
T287927-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,439.90 | |
T287927-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $3,899.90 |
Potent and selective Tpl2 (Cot; MAP3K8) inhibitor
Synonyms | Tpl2 Kinase Inhibitor|871307-18-5|4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile|Tpl2 Kinase Inhibitor 1|TC-S 7006|4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-[(3-PYRIDINYLMETHYL)AMINO]-1,7-NAPHTHYRIDINE-3-CARBO |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50= 50 nM). Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. Inhibits LPS-induced TNF-αsecretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferationin vitro. Also redu |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of mitogen-activated protein kinase kinase kinase 8 |
Product Description |
Tpl2 Kinase Inhibitor 1 is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 plays an important role in the regulation of the inflammatory response and the progression of some cancers.
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IUPAC Name | 4-(3-chloro-4-fluoroanilino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile |
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INCHI | InChI=1S/C21H14ClFN6/c22-17-6-15(3-4-18(17)23)29-21-14(8-24)11-26-19-12-28-20(7-16(19)21)27-10-13-2-1-5-25-9-13/h1-7,9,11-12H,10H2,(H,26,29)(H,27,28) |
InChi Key | NMEUKWOOQOHUNA-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=CN=C1)CNC2=NC=C3C(=C2)C(=C(C=N3)C#N)NC4=CC(=C(C=C4)F)Cl |
Isomeric SMILES | C1=CC(=CN=C1)CNC2=NC=C3C(=C2)C(=C(C=N3)C#N)NC4=CC(=C(C=C4)F)Cl |
PubChem CID | 9549300 |
Molecular Weight | 404.83 |
PubChem CID | 9549300 |
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ChEMBL Ligand | CHEMBL200381 |
CAS Registry No. | 871307-18-5 |
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Solubility | Solvent:DMSO, Max Conc. mg/mL: 40.48, Max Conc. mM: 100 |
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Sensitivity | Moisture sensitive |