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TCMDC-135051 , CAS No.T614355, Plasmodium falciparum cyclin-dependent-like kinase CLK3

TCMDC-135051 , CAS No.T614355, Plasmodium falciparum cyclin-dependent-like kinase CLK3

Item Number

T614355

Grouped product items
SKU	Size	Availability	Price	Qty
T614355-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$317.90
T614355-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$950.90

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Basic Description

Grade	Moligand™
Mechanism of action	Plasmodium falciparum cyclin-dependent-like kinase CLK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	4-[2-[3-(diethylaminomethyl)-2-methoxyphenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-propan-2-ylbenzoic acid
INCHI	InChI=1S/C29H33N3O3/c1-6-32(7-2)17-20-9-8-10-23(27(20)35-5)26-16-25-21(13-14-30-28(25)31-26)19-11-12-22(29(33)34)24(15-19)18(3)4/h8-16,18H,6-7,17H2,1-5H3,(H,30,31)(H,33,34)
InChi Key	LVVFYPXMXIDWRP-UHFFFAOYSA-N
Canonical SMILES	CCN(Cc1cccc(c1OC)c1cc2c([nH]1)nccc2c1ccc(c(c1)C(C)C)C(=O)O)CC
Isomeric SMILES	CCN(CC)CC1=C(C(=CC=C1)C2=CC3=C(C=CN=C3N2)C4=CC(=C(C=C4)C(=O)O)C(C)C)OC
PubChem CID	44528327

PubChem CID	44528327
ChEMBL Ligand	CHEMBL531865

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1. Mahindra A, Janha O, Mapesa K, Sanchez-Azqueta A, Alam MM, Amambua-Ngwa A, Nwakanma DC, Tobin AB, Jamieson AG. (2020) Development of Potent PfCLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials.. J Med Chem, 63 (17): (9300-9315). [PMID:32787140]
2. Alam MM, Sanchez-Azqueta A, Janha O, Flannery EL, Mahindra A, Mapesa K, Char AB, Sriranganadane D, Brancucci NMB, Antonova-Koch Y et al.. (2019) Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target.. Science, 365 (6456): (589-97). [PMID:31467193]

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