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TCN 201 - 98%, high purity , CAS No.852918-02-6, Allosteric modulator of GluN2A
GluN1/GluN2A-selective NMDA antagonist
Basic Description Synonyms 852918-02-6|tcn-201|TCN 201|N-(4-(2-benzoylhydrazinecarbonyl)benzyl)-3-chloro-4-fluorobenzenesulfonamide|3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide|TCN201|CHEMBL2333945|N-[[4-(benzamidocarbamoyl)phenyl]methyl]- Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms NMDA receptor antagonist selective for GluN1/GluN2A (formally NR1/NR2A) over GluN1/GluN2B (formally NR1/NR2B) containing receptors (pIC50values are 6.8 and <4.3, respectively, in human recombinant GluN1/GluN2A (formally NR1/NR2A) and GluN1/GluN2B (formal Storage Temp Protected from light,Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ALLOSTERIC MODULATOR Mechanism of action Allosteric modulator of GluN2A
Names and Identifiers Pubchem Sid 488194997 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488194997 IUPAC Name N-[[4-(benzamidocarbamoyl)phenyl]methyl]-3-chloro-4-fluorobenzenesulfonamide INCHI InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28) InChi Key FYIBXBFDXNPBSF-UHFFFAOYSA-N Canonical SMILES C1=CC=C(C=C1)C(=O)NNC(=O)C2=CC=C(C=C2)CNS(=O)(=O)C3=CC(=C(C=C3)F)Cl Isomeric SMILES C1=CC=C(C=C1)C(=O)NNC(=O)C2=CC=C(C=C2)CNS(=O)(=O)C3=CC(=C(C=C3)F)Cl WGK Germany 3 PubChem CID 4787937 Molecular Weight 366.46
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 46.19, Max Conc. mM: 100 Sensitivity Light sensitive;Moisture sensitive
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3
References 1. Bettini E, Sava A, Griffante C, Carignani C, Buson A, Capelli AM, Negri M, Andreetta F, Senar-Sancho SA, Guiral L et al. . (2010) Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.. J Pharmacol Exp Ther, 335 (3): (636-44). [PMID:20810618 ] 2. Hansen KB, Ogden KK, Traynelis SF. (2012) Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.. J Neurosci, 32 (18): (6197-208). [PMID:22553026 ]
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