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TCN 238 - ≥98%(HPLC), high purity , CAS No.125404-04-8, Allosteric modulator of mGlu 4 receptor

Moligand™
≥98%(HPLC)

CAS#: 125404-04-8
Formula: C₁₂H₁₁N₃
Molecular Weight: 197.24
PubChem CID: 46911068

Item Number

T287796

Grouped product items
SKU	Size	Availability	Price
T287796-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$64.90
T287796-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$113.90
T287796-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$244.90
T287796-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$423.90
T287796-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$739.90

Positive allosteric modulator of mGlu4receptors

View related series

mGlu4 receptor Allosteric modulator

Basic Description

Synonyms	125404-04-8\|TCN 238\|TCN238\|(E)-4-(2-Phenylethenyl)-2-pyrimidinamine\|4-[(E)-2-phenylethenyl]pyrimidin-2-amine\|Lu AF32615\|CHEMBL1209431\|compound 11 [PMID: 20638279]\|3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4-ylethoxy)-4h-chromen-4-one\|GTPL6235\|DTXSID00
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Positive allosteric modulator of mGlu4receptors (EC50= 1.0μM for human and rat mGlu4receptors). Orally available and brain penetrant.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of mGlu 4 receptor

Associated Targets

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA2A Tclin Adenosine receptor A2a 0 Activities

Discover Target: ADORA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

Discover Target: ADRA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

Discover Target: HTR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM4 Tchem Metabotropic glutamate receptor 4 1 Activities

Discover Target: GRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM5 Tchem Metabotropic glutamate receptor 5 0 Activities

Discover Target: GRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[(E)-2-phenylethenyl]pyrimidin-2-amine
INCHI	InChI=1S/C12H11N3/c13-12-14-9-8-11(15-12)7-6-10-4-2-1-3-5-10/h1-9H,(H2,13,14,15)/b7-6+
InChi Key	LNUXNUNUGIHCPA-VOTSOKGWSA-N
Canonical SMILES	C1=CC=C(C=C1)C=CC2=NC(=NC=C2)N
Isomeric SMILES	C1=CC=C(C=C1)/C=C/C2=NC(=NC=C2)N
Alternate CAS	125404-04-8
PubChem CID	46911068
MeSH Entry Terms	3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4-ylethoxy)-4H-chromen-4-one;CFMMC cpd
Molecular Weight	197.24

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
C2210488	Certificate of Analysis	Feb 14, 2022	T287796
C2210490	Certificate of Analysis	Feb 14, 2022	T287796
C2210575	Certificate of Analysis	Feb 14, 2022	T287796
C2210600	Certificate of Analysis	Feb 14, 2022	T287796
C2210601	Certificate of Analysis	Feb 14, 2022	T287796

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P501:Dispose of contents/container to ... P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P403+P233:Store in a well-ventilated place. Keep container tightly closed.

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