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TCS JNK 5a - ≥99%(HPLC), high purity , CAS No.312917-14-9, Inhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 9

  • Moligand™
  • ≥99%(HPLC)
Item Number
T287056
Grouped product items
SKUSizeAvailabilityPrice Qty
T287056-5mg
5mg
In stock
$48.90
T287056-10mg
10mg
In stock
$78.90
T287056-25mg
25mg
In stock
$177.90
T287056-50mg
50mg
In stock
$236.90
T287056-100mg
100mg
In stock
$365.90
T287056-250mg
250mg
In stock
$823.90
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Selective inhibitor of JNK2 and JNK3

View related series
mitogen-activated protein kinase 10 Inhibitor mitogen-activated protein kinase 9 Inhibitor

Basic Description

Synonyms312917-14-9|TCS JNK 5a|JNK Inhibitor IX|N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-naphthamide|SC-202671|N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide|TCS JNK 5a (JNK Inhibitor IX)|GW620972X|N-(3-Cyano-4,5,6,7-tet
Specifications & PurityMoligand™, ≥99%(HPLC)
Biochemical and Physiological MechanismsSelective inhibitor of JNK2 and JNK3 (pIC50values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38αrespectively). Displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC50< 5.0).
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 9

Names and Identifiers

Pubchem Sid488191451
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488191451
IUPAC Name N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
INCHI InChI=1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23)
InChi Key WQGDQGAFSDMBLA-UHFFFAOYSA-N
Canonical SMILES C1CCC2=C(C1)C(=C(S2)NC(=O)C3=CC=CC4=CC=CC=C43)C#N
Isomeric SMILES C1CCC2=C(C1)C(=C(S2)NC(=O)C3=CC=CC4=CC=CC=C43)C#N
PubChem CID 766949
Molecular Weight 332.42

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
K2228667Certificate of AnalysisSep 16, 2022 T287056
K2228668Certificate of AnalysisSep 16, 2022 T287056
K2228669Certificate of AnalysisSep 16, 2022 T287056
K2228670Certificate of AnalysisSep 16, 2022 T287056
K2228671Certificate of AnalysisSep 16, 2022 T287056
K2228672Certificate of AnalysisSep 16, 2022 T287056
K2228682Certificate of AnalysisSep 16, 2022 T287056
K2228777Certificate of AnalysisSep 16, 2022 T287056

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 33.24, Max Conc. mM: 100
Sensitivitylight sensitive

Related Documents

 SDS

 Specification Sheet

References

1. Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y et al..  (2001)  SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase..  Proc Natl Acad Sci USA,  98  (24): (13681-6).  [PMID:11717429]

Solution Calculators

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