Teclistamab (anti-CD3&BCMA) - Primary antibody, specific to CD3E & TNFRSF17, Human IgG4SP, BINDING AGENT of T cell surface glycoprotein CD3 binding agent

Features and benefits

Short Overview:
Purity≥90% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Species reactivity(Reacts with): Human
Isotype: Human IgG4SP

Application:

Item Number

Ab175669

Grouped product items
SKU	Size	Availability	Price
Ab175669-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$239.90
Ab175669-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,189.90
Ab175669-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,999.90
Ab175669-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,999.90

Purity≥90% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

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Basic Description

Product Name	Teclistamab (anti-CD3&BCMA) - Primary antibody, specific to CD3E & TNFRSF17, Human IgG4SP
Synonyms	JNJ-64007957;teclistamab-cqyv;Tecvayli
Specifications & Purity	ExactAb™, Low Endotoxin, Azide Free, Carrier Free, Validated, Recombinant, ≥90%(SDS-PAGE&SEC), Lot by Lot
Specificity	CD3E & TNFRSF17
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	BINDING AGENT
Mechanism of action	BINDING AGENT of T cell surface glycoprotein CD3 binding agent
Product Description	Teclistamab (anti-CD3 & BCMA) is a human bispecific antibody to BCMA and CD3 that recognizes BCMA on target cells and CD3 on T cells and induces T cell-mediated cytotoxicity leading to T cell activation and subsequent target cell lysis. Teclistamab (anti-CD3 & BCMA) can be used in studies of diseases related to multiple myeloma (MM). Purity ≥90% (SDS-PAGE&SEC) Endotoxin Level ≤1.0EU/mg

Product Properties

Isotype	Human IgG4SP
Light Chain Type	kappa
SDS-PAGE	143.64 kDa
Purification Method	Protein A purified
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	2119595-80-9

References

1. Pillarisetti K, Powers G, Luistro L, Babich A, Baldwin E, Li Y, Zhang X, Mendonça M, Majewski N, Nanjunda R et al.. (2020) Teclistamab is an active T cell-redirecting bispecific antibody against B-cell maturation antigen for multiple myeloma.. Blood Adv, 4 (18): (4538-4549). [PMID:32956453]
2. Moreau P, Garfall AL, van de Donk NWCJ, Nahi H, San-Miguel JF, Oriol A, Nooka AK, Martin T, Rosinol L, Chari A et al.. (2022) Teclistamab in Relapsed or Refractory Multiple Myeloma.. N Engl J Med, 387 (6): (495-505). [PMID:35661166]
3. Chan CL, Jones RL, Lau HY. (2022) Teclistamab Approved for Myeloma.. Cancer Discov, 129 (3): (OF1). [PMID:36321843]

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Basic Description