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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T646437-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $166.90 | |
T646437-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $350.90 | |
T646437-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $580.90 | |
T646437-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,100.90 | |
T646437-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,700.90 | |
T646437-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,500.90 |
Specifications & Purity | ≥99% |
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Biochemical and Physiological Mechanisms | Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. Teplinovivint has anti-inflammatory activity and has the potential for tendinopathy research. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. Teplinovivint has anti-inflammatory activity and has the potential for tendinopathy research. In Vitro Teplinovivint (compound 175; 0.0003-10 μM) inhibits Wnt/p-catenin activity in human colorectal cancecell line (SW480) in a dose-dependent manner (EC 50 =152.9 nM). Teplinovivint inhibits SW480 cells (EC 50 =25 nM) and primary human mesenchymal stem cells (hMSCs; EC 50 =10.377 μM). Teplinovivint (5.8, 10.8, 21.7, 41.7, 83.3, 166.6, 333.3, 750 nM) induced the expression of SCXA, TenacinC and Tenomodulin, in a dose-dependent manner with an EC 50 between 139-189 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Teplinovivint (compound 175; 10 mg/ml; once daily for 21 days via topical application) causes amelioration of inflammation as well as tendon degeneration. Teplinovivint results in a decrease of aninflammatory plasma biomarker, KC/GRO in the Collagenase-induced Tendon Injury Model . Teplinovivint (1 mg/ml with 1% BA) has a T max of 1 hours in plasma . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
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Canonical SMILES | COC1=NC=C(C=C1)NC(=O)C2=NNC3=C2C=C(C=C3)C4=CN=CC(=C4)CN5CCCCC5 |
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Isomeric SMILES | COC1=NC=C(C=C1)NC(=O)C2=NNC3=C2C=C(C=C3)C4=CN=CC(=C4)CN5CCCCC5 |
PubChem CID | 89451003 |
Molecular Weight | 442.51 |
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Solubility | DMSO : 83.33 mg/mL (188.31 mM; Need ultrasonic) |
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