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tert-Butyl bicyclo[2.2.2]phosphorothionate , CAS No.70636-86-1, Channel blocker of GABA A receptor α1 subunit;Channel blocker of GABA A receptor α2 subunit;Channel blocker of GABA A receptor α3 subunit;Channel blocker of GABA A receptor α4 subunit;Channel blocker of GABA A receptor α5 subunit;Channel blocker of GABA A

Moligand™

CAS#: 70636-86-1
Formula: C₈H₁₅O₃PS
Molecular Weight: 222.24
PubChem CID: 104781

Item Number

T335874

Grouped product items
SKU	Size	Availability	Price	Qty
T335874-2mg	2mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$399.90

a GABAAreceptor antagonist

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Basic Description

Synonyms	TBPS\|tert-Butylbicyclophosphorothionate\|70636-86-1\|tert-Butyl bicyclo[2.2.2]phosphorothionate\|t-butylbicyclophosphorothionate\|4-tert-butyl-1-sulfanylidene-2,6,7-trioxa-1lambda5-phosphabicyclo[2.2.2]octane\|2,6,7-Trioxa-1-phosphabicyclo(2.2.2)octane, 4-(1,1
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of GABA A receptor α1 subunit;Channel blocker of GABA A receptor α2 subunit;Channel blocker of GABA A receptor α3 subunit;Channel blocker of GABA A receptor α4 subunit;Channel blocker of GABA A receptor α5 subunit;Channel blocker of GABA A
Product Description	tert-Butyl bicyclo[2.2.2]phosphorothionate is a GABA\|A\|receptor antagonist, chloride channel blocker and an extremely potent convulsant.

Associated Targets

GABRR1 Tchem Gamma-aminobutyric acid receptor subunit rho-1 0 Activities

Discover Target: GABRR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRR3 Tbio Gamma-aminobutyric acid receptor subunit rho-3 0 Activities

Discover Target: GABRR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

Discover Target: GABRA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRD Tclin Gamma-aminobutyric acid receptor subunit delta 0 Activities

Discover Target: GABRD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRG3 Tclin Gamma-aminobutyric acid receptor subunit gamma-3 0 Activities

Discover Target: GABRG3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRG1 Tclin Gamma-aminobutyric acid receptor subunit gamma-1 0 Activities

Discover Target: GABRG1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRG2 Tclin Gamma-aminobutyric acid receptor subunit gamma-2 0 Activities

Discover Target: GABRG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA3 Tclin Gamma-aminobutyric acid receptor subunit alpha-3 0 Activities

Discover Target: GABRA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA4 Tclin Gamma-aminobutyric acid receptor subunit alpha-4 0 Activities

Discover Target: GABRA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA5 Tclin Gamma-aminobutyric acid receptor subunit alpha-5 0 Activities

Discover Target: GABRA5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRB1 Tclin Gamma-aminobutyric acid receptor subunit beta-1 0 Activities

Discover Target: GABRB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRB3 Tclin Gamma-aminobutyric acid receptor subunit beta-3 0 Activities

Discover Target: GABRB3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRP Tclin Gamma-aminobutyric acid receptor subunit pi 0 Activities

Discover Target: GABRP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRQ Tclin Gamma-aminobutyric acid receptor subunit theta 0 Activities

Discover Target: GABRQ

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRE Tclin Gamma-aminobutyric acid receptor subunit epsilon 0 Activities

Discover Target: GABRE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRR2 Tchem Gamma-aminobutyric acid receptor subunit rho-2 0 Activities

Discover Target: GABRR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA2 Tclin Gamma-aminobutyric acid receptor subunit alpha-2 0 Activities

Discover Target: GABRA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA6 Tclin Gamma-aminobutyric acid receptor subunit alpha-6 0 Activities

Discover Target: GABRA6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRB2 Tclin Gamma-aminobutyric acid receptor subunit beta-2 0 Activities

Discover Target: GABRB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-tert-butyl-1-sulfanylidene-2,6,7-trioxa-1λ5-phosphabicyclo[2.2.2]octane
INCHI	InChI=1S/C8H15O3PS/c1-7(2,3)8-4-9-12(13,10-5-8)11-6-8/h4-6H2,1-3H3
InChi Key	VTBHBNXGFPTBJL-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C12COP(=S)(OC1)OC2
Isomeric SMILES	CC(C)(C)C12COP(=S)(OC1)OC2
WGK Germany	3
RTECS	TG0782500
PubChem CID	104781
Molecular Weight	222.24

PubChem CID

104781

CAS Registry No.

70636-86-1

ChEMBL Ligand

CHEMBL485673

WGK Germany

RTECS

TG0782500

RIDADR

NONHforallmodesoftransport

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