Tetrabutylammonium fluoride trihydrate is a mild base used in reactions like aldol-type condensation reactions, Michael-type reactions, ring-opening reactions. Its is also used as a promoter in cross-coupling reactions and cyclization of carbocycles and heterocycles.参考sigma
application：
Reactant for:
Preparation of deprotecting agents in preparation of cellulose derivatives
Synthesis of lipophilic peptides for DNA transfections in vivo
Dehydrobromination reactions
Tetrabutylammonium fluoride trihydrate can be used as a base:
For the dehydrobromination of vinyl bromides to terminal acetylenes.
In the conversion of 1,1-dibromo-1-alkenes to terminal alkynes via Corey–Fuchs reaction.
In Hiyama cross-coupling reaction of aryl and heteroaryl chlorides with aryltrialkoxysilanes in the presence of a palladium catalyst.
It can be used to catalyze ethynylation of quinolines and isoquinolines using calcium carbide in aqueous N,N-dimethylacetamide.
1.Delia López-Velázquez,Armando R Hernández-Sosa,Ernesto Pérez. (2015-04-11) Effect of the degree of substitution in the transition temperatures and hydrophobicity of hydroxypropyl cellulose esters.. Carbohydrate polymers, 125 (224-231). [PMID:25857978]
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