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TFC 007 - ≥98%(HPLC), high purity , CAS No.927878-49-7, Inhibitor of H-PGDS

  • Moligand™
  • ≥98%(HPLC)
Item Number
T287081
Grouped product items
SKUSizeAvailabilityPrice Qty
T287081-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
T287081-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
T287081-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90
T287081-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$699.90
T287081-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$999.90
T287081-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,599.90

Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor

View related series
H-PGDS Inhibitor

Basic Description

SynonymsN-[4-[4-(4-Morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide
Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsPotent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor (IC50= 83 nM). Inhibits PGD2production and late phase nasal blockage in an animal model of allergic rhinitis. Exhibits negligible effects on COX-1, COX-2, 5-LOX, LTC4synthase, TXA2synthase a
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of H-PGDS

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CRBN Tclin Protein cereblon 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HPGDS Tchem Hematopoietic prostaglandin D synthase 4 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-[4-[4-(morpholine-4-carbonyl)piperidin-1-yl]phenyl]-2-phenoxypyrimidine-5-carboxamide
INCHI InChI=1S/C27H29N5O4/c33-25(21-18-28-27(29-19-21)36-24-4-2-1-3-5-24)30-22-6-8-23(9-7-22)31-12-10-20(11-13-31)26(34)32-14-16-35-17-15-32/h1-9,18-20H,10-17H2,(H,30,33)
InChi Key NLSSUSRERAMBTA-UHFFFAOYSA-N
Canonical SMILES C1CN(CCC1C(=O)N2CCOCC2)C3=CC=C(C=C3)NC(=O)C4=CN=C(N=C4)OC5=CC=CC=C5
Isomeric SMILES C1CN(CCC1C(=O)N2CCOCC2)C3=CC=C(C=C3)NC(=O)C4=CN=C(N=C4)OC5=CC=CC=C5
PubChem CID 16040067
Molecular Weight 487.55

Certificates

Certificate of Analysis(COA)

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12 results found

Lot NumberCertificate TypeDateItem
E2431367Certificate of AnalysisFeb 26, 2024 T287081
E2431380Certificate of AnalysisFeb 26, 2024 T287081
E2431472Certificate of AnalysisFeb 26, 2024 T287081
E2431473Certificate of AnalysisFeb 26, 2024 T287081
E2431474Certificate of AnalysisFeb 26, 2024 T287081
E2431475Certificate of AnalysisFeb 26, 2024 T287081
E2431476Certificate of AnalysisFeb 26, 2024 T287081
E2431477Certificate of AnalysisFeb 26, 2024 T287081
E2431478Certificate of AnalysisFeb 26, 2024 T287081
E2431479Certificate of AnalysisFeb 26, 2024 T287081
E2431480Certificate of AnalysisFeb 26, 2024 T287081
E2431481Certificate of AnalysisFeb 26, 2024 T287081

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 48.76, Max Conc. mM: 100

Related Documents

References

1. Takaya D, Inaka K, Omura A, Takenuki K, Kawanishi M, Yabuki Y, Nakagawa Y, Tsuganezawa K, Ogawa N, Watanabe C et al..  (2018)  Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies..  Bioorg Med Chem,  26  (16): (4726-4734).  [PMID:30121213]

Solution Calculators