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TG 4-155 - ≥98%(HPLC), high purity , CAS No.1164462-05-8, Antagonist of EP 2 receptor
High affinity and selective EP2receptor antagonist
Basic Description Synonyms (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide;TG4-155 Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms High affinity and selective EP2receptor antagonist (KBvalues are 2.4 and 34.5 nM for EP2and DP1receptors respectively). Exhibits >500-fold selectivity for EP2over other prostanoid receptors. Inhibits butaprost-induced proinflammatory cytokine production, Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of EP 2 receptor
Names and Identifiers IUPAC Name (E)-N-[2-(2-methylindol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide INCHI InChI=1S/C23H26N2O4/c1-16-13-18-7-5-6-8-19(18)25(16)12-11-24-22(26)10-9-17-14-20(27-2)23(29-4)21(15-17)28-3/h5-10,13-15H,11-12H2,1-4H3,(H,24,26)/b10-9+ InChi Key YBHUXHFZLMFETJ-MDZDMXLPSA-N Canonical SMILES CC1=CC2=CC=CC=C2N1CCNC(=O)C=CC3=CC(=C(C(=C3)OC)OC)OC Isomeric SMILES CC1=CC2=CC=CC=C2N1CCNC(=O)/C=C/C3=CC(=C(C(=C3)OC)OC)OC PubChem CID 5886965 MeSH Entry Terms TG4-155 Molecular Weight 394.46
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 39.45, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 7.89, Max Conc. mM: 20 Sensitivity air sensitive
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P337+P313: IF eye irritation persists: Get medical advice/attention.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P332+P313: IF SKIN irritation occurs: Get medical advice/attention.
P304+P340+P312: IF INHALED: Remove person to fresh air and keep comfortable for breathing.Call a POISON CENTER or doctor. if you feel unwell.
RIDADR NONHforallmodesoftransport
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J2116083