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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T650025-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,050.90 |
Flavonoids Flavones Phenols Polyphenols
Specifications & Purity | ≥98% |
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Biochemical and Physiological Mechanisms | Thevetiaflavone could upregulate the expression of Bcl-2 and downregulate that of Bax and caspase-3 . |
Storage Temp | Protected from light,Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | Thevetiaflavone could upregulate the expression of Bcl‑2 and downregulate that of Bax and caspase‑3 . In Vitro Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS‑mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca 2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl‑2 and downregulating that of Bax and caspase‑3 in addition to increasing the activity of caspase‑3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Bcl-2 Bax Caspase-3 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 7-hydroxy-2-(4-hydroxyphenyl)-5-methoxychromen-4-one |
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INCHI | InChI=1S/C16H12O5/c1-20-14-6-11(18)7-15-16(14)12(19)8-13(21-15)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3 |
InChi Key | YQABHAHJGSNVQR-UHFFFAOYSA-N |
Canonical SMILES | COC1=CC(=CC2=C1C(=O)C=C(O2)C3=CC=C(C=C3)O)O |
Isomeric SMILES | COC1=CC(=CC2=C1C(=O)C=C(O2)C3=CC=C(C=C3)O)O |
PubChem CID | 5315202 |
NSC Number | 719158 |
Molecular Weight | 284.26 |
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