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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T650853-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $180.90 | |
T650853-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $280.90 | |
T650853-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $520.90 | |
T650853-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $800.90 | |
T650853-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,200.90 |
Specifications & Purity | ≥99% |
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Biochemical and Physiological Mechanisms | ThioLox is a competitive 15-lipoxygenase-1 ( 15-LOX-1 ) inhibitor with a K i of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | ThioLox is a competitive 15-lipoxygenase-1 ( 15-LOX-1 ) inhibitor with a K i of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties In Vitro ThioLox shows competitive inhibition thus indicating non-covalent interaction with the active site of the 15-LOX-1. ThioLox (50 μM; 24 h) inhibits interleukin (IL-1β, IL-6, IL-8, IL-12b, TNFα and iNOS) expression in precision-cut lung slices (PCLS). ThioLox (10 μM; 16 h) prevent lipid peroxidation and mitochondrial superoxide formation in neuronal cells. ThioLox (5-20 μM; 14-16 h) protects HT-22 cells against glutamate toxicity and significantly reduces neuronal cell death. MCE has not independently confirmed the accuracy of these methods. They are for reference only. RT-PCRCell Line: Precision-cut lung slices (PCLS) Concentration: 1, 5, 10, 25 and 50 μM Incubation Time: In combination with 10 μM linoleic acid for 20 h and stimulated with 10 ng/mL LPS for the last 4 h. Result: Provided almost 50% inhibition of the expression of the pro-inflammatory genes IL-1β, IL-6, IL-8, IL-12b, TNFα and iNOS at 50 μM. Cell Viability AssayCell Line: Neuronal HT-22 cells Concentration: 5, 10 and 20 μM Incubation Time: 14-16 h Result: Significantly reduced neuronal cell death against glutamate toxicity. In Vivo ThioLox has a logP of 3 and shows values that comply very well with the BBB permeability . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 3.30 μM (15-LOX-1) |
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IUPAC Name | 2-amino-N-butyl-5-phenylthiophene-3-carboxamide |
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INCHI | InChI=1S/C15H18N2OS/c1-2-3-9-17-15(18)12-10-13(19-14(12)16)11-7-5-4-6-8-11/h4-8,10H,2-3,9,16H2,1H3,(H,17,18) |
InChi Key | QWWMJRJCSZMXHZ-UHFFFAOYSA-N |
Canonical SMILES | CCCCNC(=O)C1=C(SC(=C1)C2=CC=CC=C2)N |
Isomeric SMILES | CCCCNC(=O)C1=C(SC(=C1)C2=CC=CC=C2)N |
PubChem CID | 53383638 |
Molecular Weight | 274.38 |
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Solubility | DMSO : 100 mg/mL (364.46 mM; ultrasonic and warming and heat to 60°C) |
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