Thioredoxin 2 Antibody - Primary antibody, specific to TXN2, Rabbit IgG

Features and benefits
  • Short Overview:

    pAb; Rabbit anti Human Thioredoxin 2 Antibody; WB; Unconjugated

  • Species reactivity(Reacts with): Human,Mouse,Rat
  • Isotype: Rabbit IgG
    Application:
  • WB
Item Number
Ab130982
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab130982-10μl
10μl
In stock
$69.90
Ab130982-50μl
50μl
In stock
$199.90
Ab130982-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$309.90
Ab130982-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,699.90

pAb; Rabbit anti Human Thioredoxin 2 Antibody; WB; Unconjugated

Basic Description

Product NameThioredoxin 2 Antibody - Primary antibody, specific to TXN2, Rabbit IgG
SynonymsMTRX | Mt-Trx | Thioredoxin-2 | mitochondrial thioredoxin antibody | MT-TRX antibody | MTRX antibody | thioredoxin 2 precursor antibody | Thioredoxin mitochondrial antibody | Thioredoxin2 antibody | TRX 2 antibody | TRX2 antibody | TXN 2 antibody | TXN2 a
Specifications & PurityExactAb™, Validated, Carrier Free, 2.0 mg/mL
Host speciesRabbit
SpecificityTXN2
ImmunogenA KLH conjugated synthetic peptide from the C-terminal region of human Thioredoxin 2 (AA 136-166)
Positive ControlWB: Hep G2, HeLa, K562, Jurkat, Raji, NIH/3T3 and C6 cell lysates.
ConjugationUnconjugated
GradeCarrier Free, ExactAb™, Validated
Product Description

Rabbit anti Human Thioredoxin 2 Antibody, Polyclonal, could be used for WB and so on.
Application:
WB: 1/1000
Protein Function
Thioredoxin is a small redox protein found in many eukaryotes and prokaryotes. A pair of cysteines within a highly conserved, active site sequence can be oxidized to form a disulfide bond that is then reduced by thioredoxin reductase (1). Multiple forms of thioredoxin have been identified, including cytosolic thioredoxin 1 (TRX1) and mitochondrial thioredoxin 2 (TRX2). Thioredoxin participates in many cellular processes including redox signaling, response to oxidative stress, and protein reduction (1). A potential role of thioredoxin in human disorders such as cancer, aging, and heart disease is currently under investigation (2). Thioredoxin can play a key role in cancer progression, because it acts as a negative regulator of the proapoptotic kinase ASK1 (3). Changes in thioredoxin expression have been associated with meningococcal septic shock and acute lung injury (4,5).

Product Properties

IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodSaturated ammonium sulfate precipitation
FormLiquid
Concentration2.0 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4℃ short term (2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Thioredoxin 2 Antibody (Ab130982) - Western Blot
All lanes: Thioredoxin 2 Antibody (Ab130982) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 18 kDa
Observed band size: 13 kDa
Exposure time: 10.9 s

Associated Targets(Human)

TXN2 Tbio Thioredoxin, mitochondrial (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TXN2 Tbio Thioredoxin, mitochondrial (16 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Application

ApplicationDilution info
WB

1/1000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
ZJ24F0403962Certificate of AnalysisApr 01, 2024 Ab130982
ZJ24F0403963Certificate of AnalysisApr 01, 2024 Ab130982

Related Documents

References

1. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.  (2009)  Lysine acetylation targets protein complexes and co-regulates major cellular functions..  Science,  325  (5942): (834-40).  [PMID:19608861]
2. Damdimopoulos AE, Miranda-Vizuete A, Pelto-Huikko M, Gustafsson JA, Spyrou G..  ()  Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death..  J Biol Chem,      [PMID:12080052]
3. Dunham, I I and 24 more authors..  (1999)  The DNA sequence of human chromosome 22..  Nature,    (2):   [PMID:10591208]
4. Chen, Yan Y, Cai, Jiyang J, Murphy, T J TJ and Jones, Dean P DP..  (2002)  Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells..  The Journal of biological chemistry,    (6):   [PMID:12032145]
5. Collins, John E JE and 12 more authors..  (2004)  A genome annotation-driven approach to cloning the human ORFeome..  Genome biology,      [PMID:15461802]
6. Holzerova, Eliska E and 17 more authors..  (2016)  Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration..  Brain : a journal of neurology,      [PMID:26626369]

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