| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| T465851-1EA | 1EA | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,241.90 |
| Specifications & Purity | 0.2 μm sterile filtered, suitable for 3D bioprinting applications |
|---|---|
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | Description 3D bioprinting is the printing of biocompatible materials, cells, growth factors, and the other supporting materials necessary to yield functional complex living tissues. 3D bioprinting has been used to generate several different types of tissue such as skin, bone, vascular grafts, and cartilage structures. Based upon the desired properties, different materials and formulations can be used to generate both hard and soft tissues. While several 3D printing methods exist, due to the sensitivity of the materials used, extrusion-based methods with bioinks are most commonly employed.Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation. In addition to fast gelation, the methacrylamide functional group can also be used to control the hydrogel physical parameters such as pore size, degradation rate, and swell ratio. Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies. Gelatin methacrylate based bioinks have been used to bioprint osteogenic, chondrogenic, hepatic, adipogenic, vasculogenic, epithelial, endothelial, cardiac valve, skin, tumor and other tissues and constructs. |
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| 1. Aleksander Skardal,Jianxing Zhang,Lindsi McCoard,Xiaoyu Xu,Siam Oottamasathien,Glenn D Prestwich. (2010-04-15) Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting.. Tissue engineering. Part A, 16 ((8)): (2675-2685). [PMID:20387987] |
| 2. Wouter Schuurman,Peter A Levett,Michiel W Pot,Paul René van Weeren,Wouter J A Dhert,Dietmar W Hutmacher,Ferry P W Melchels,Travis J Klein,Jos Malda. (2013-02-20) Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs.. Macromolecular bioscience, 13 ((5)): (551-561). [PMID:23420700] |
| 3. Thomas Billiet,Elien Gevaert,Thomas De Schryver,Maria Cornelissen,Peter Dubruel. (2013-10-12) The 3D printing of gelatin methacrylamide cell-laden tissue-engineered constructs with high cell viability.. Biomaterials, 35 ((1)): (49-62). [PMID:24112804] |
| 4. B Duan,E Kapetanovic,L A Hockaday,J T Butcher. (2013-12-18) Three-dimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells.. Acta biomaterialia, 10 ((5)): (1836-1846). [PMID:24334142] |
| 5. Luiz E Bertassoni,Juliana C Cardoso,Vijayan Manoharan,Ana L Cristino,Nupura S Bhise,Wesleyan A Araujo,Pinar Zorlutuna,Nihal E Vrana,Amir M Ghaemmaghami,Mehmet R Dokmeci,Ali Khademhosseini. (2014-04-04) Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels.. Biofabrication, 6 ((2)): (024105-024105). [PMID:24695367] |
| 6. Janet R Xavier,Teena Thakur,Prachi Desai,Manish K Jaiswal,Nick Sears,Elizabeth Cosgriff-Hernandez,Roland Kaunas,Akhilesh K Gaharwar. (2015-02-13) Bioactive nanoengineered hydrogels for bone tissue engineering: a growth-factor-free approach.. ACS nano, 9 ((3)): (3109-3118). [PMID:25674809] |
| 7. Birgit Huber,Kirsten Borchers,Günter Em Tovar,Petra J Kluger. (2015-05-29) Methacrylated gelatin and mature adipocytes are promising components for adipose tissue engineering.. Journal of biomaterials applications, 30 ((6)): (699-710). [PMID:26017717] |
| 8. Marco Costantini,Joanna Idaszek,Krisztina Szöke,Jakub Jaroszewicz,Mariella Dentini,Andrea Barbetta,Jan E Brinchmann,Wojciech Święszkowski. (2016-07-20) 3D bioprinting of BM-MSCs-loaded ECM biomimetic hydrogels for in vitro neocartilage formation.. Biofabrication, 8 ((3)): (035002-035002). [PMID:27431574] |
| 9. Weitao Jia,P Selcan Gungor-Ozkerim,Yu Shrike Zhang,Kan Yue,Kai Zhu,Wanjun Liu,Qingment Pi,Batzaya Byambaa,Mehmet Remzi Dokmeci,Su Ryon Shin,Ali Khademhosseini. (2016-08-24) Direct 3D bioprinting of perfusable vascular constructs using a blend bioink.. Biomaterials, 106 (58-68). [PMID:27552316] |
| 10. Christine McBeth,Jasmin Lauer,Michael Ottersbach,Jennifer Campbell,Andre Sharon,Alexis F Sauer-Budge. (2017-01-11) 3D bioprinting of GelMA scaffolds triggers mineral deposition by primary human osteoblasts.. Biofabrication, 9 ((1)): (015009-015009). [PMID:28071596] |
| 11. Wanjun Liu,Zhe Zhong,Ning Hu,Yixiao Zhou,Lucia Maggio,Amir K Miri,Alessio Fragasso,Xiangyu Jin,Ali Khademhosseini,Yu Shrike Zhang. (2017-11-28) Coaxial extrusion bioprinting of 3D microfibrous constructs with cell-favorable gelatin methacryloyl microenvironments.. Biofabrication, 10 ((2)): (024102-024102). [PMID:29176035] |
| 12. Y Shi,T L Xing,H B Zhang,R X Yin,S M Yang,J Wei,W J Zhang. (2018-01-09) Tyrosinase-doped bioink for 3D bioprinting of living skin constructs.. Biomedical materials (Bristol, England), 13 ((3)): (035008-035008). [PMID:29307874] |
| 13. Jun Yin,Mengling Yan,Yancheng Wang,Jianzhong Fu,Hairui Suo. (2018-02-07) 3D Bioprinting of Low-Concentration Cell-Laden Gelatin Methacrylate (GelMA) Bioinks with a Two-Step Cross-linking Strategy.. ACS applied materials & interfaces, 10 ((8)): (6849-6857). [PMID:29405059] |
| 14. P Selcan Gungor-Ozkerim,Ilyas Inci,Yu Shrike Zhang,Ali Khademhosseini,Mehmet Remzi Dokmeci. (2018-03-02) Bioinks for 3D bioprinting: an overview.. Biomaterials science, 6 ((5)): (915-946). [PMID:29492503] |
| 15. Wanjun Liu,Marcel A Heinrich,Yixiao Zhou,Ali Akpek,Ning Hu,Xiao Liu,Xiaofei Guan,Zhe Zhong,Xiangyu Jin,Ali Khademhosseini,Yu Shrike Zhang. (2017-05-04) Extrusion Bioprinting of Shear-Thinning Gelatin Methacryloyl Bioinks.. Advanced healthcare materials, 6 ((12)): [PMID:28464555] |
