Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor
Product Description
Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.
1.Leiphart JW, Dills CV, Levy RM. (2004) Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain.. J Neurosurg, 101 (4):(641-7). [PMID:15481719]
2.Ono H, Mishima A, Ono S, Fukuda H, Vasko MR. (1991) Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by alpha-adrenergic receptor antagonists.. Neuropharmacology, 30 (6):(585-9). [PMID:1717870]
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C2317256