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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T647286-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $540.90 | |
T647286-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $880.90 |
Specifications & Purity | 98% |
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Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | TK05 is a potent and selective inhibitor of leukotriene C 4 synthase (LTC4S) with an IC 50 of 95 nM In Vitro TK05 reduces LTC 4 production in a dose-dependent manner with an IC 50 value of 318 ± 60 nM in MM6 Cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE 4 levels . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Zymosan A induced peritonitis mouse model Dosage: 0.12 mg/kg; 6 mg/kg Administration: Given i.p.; only once Result: 0.12 mg/kg of TK05 significantly reduced LTE 4 levels, whereas 6 mg/kg body weight of the compound resulted in almost complete inhibition compared with mice treated with only Zymosan A. Form:Solid IC50& Target:IC50: 95 nM (Leukotriene C 4 synthase) |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 5-[5-[4-chloro-N-(cyclopropylmethyl)anilino]pyridine-2-carbonyl]-2-(4-methoxybenzoyl)benzoic acid |
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INCHI | InChI=1S/C31H25ClN2O5/c1-39-25-12-4-20(5-13-25)29(35)26-14-6-21(16-27(26)31(37)38)30(36)28-15-11-24(17-33-28)34(18-19-2-3-19)23-9-7-22(32)8-10-23/h4-17,19H,2-3,18H2,1H3,(H,37,38) |
InChi Key | GRDDFJXOEAJYCT-UHFFFAOYSA-N |
Canonical SMILES | COC1=CC=C(C=C1)C(=O)C2=C(C=C(C=C2)C(=O)C3=NC=C(C=C3)N(CC4CC4)C5=CC=C(C=C5)Cl)C(=O)O |
Isomeric SMILES | COC1=CC=C(C=C1)C(=O)C2=C(C=C(C=C2)C(=O)C3=NC=C(C=C3)N(CC4CC4)C5=CC=C(C=C5)Cl)C(=O)O |
PubChem CID | 53385780 |
Molecular Weight | 540.99 |
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Solubility | DMSO : ≥ 100 mg/mL (184.85 mM) |
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