| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| T655209-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $132.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Dry ice |
| Product Description | (-)-TK216 is an enantiomer of TK216 ( HY-122903 ). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. (-)-TK216 has anti-cancer activity. In Vitro (-)-TK216 (compound 14; for 3 days) has an IC 50 <5 μM in SKES cells (Ewing Sarcoma cell line). (-)-TK216 has T 1/2 s of 27.7 mins, 2.8 mins, 23.1 mins and 40.8 mins for human, rat, mouse, dog liver microsomes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo (-)-TK216 (compound 14; 5 mg/kg for iv or 25 mg/kg for po) has T 1/2 s of 0.8 hours and 3.1 hours, and AUCs of 4131 h•(ng/mL) and 13152 h•(ng/mL) for iv and po, respectively, in BALB/c mice or Sprague Dawley rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Canonical SMILES | C1CC1C2=CC=C(C=C2)C(=O)CC3(C4=C(C=CC(=C4NC3=O)Cl)Cl)O |
|---|---|
| Molecular Weight | 376.23 |
Enter Lot Number to search for COA:
