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TL 12-186 - ≥98%(HPLC), high purity , CAS No.2250025-88-6, cereblon

Moligand™
≥98%(HPLC)

CAS#: 2250025-88-6
Formula: C₄₄H₅₁ClN₁₀O₉S
Molecular Weight: 931.46
PubChem CID: 134812843

Item Number

T288251

Grouped product items
SKU	Size	Availability	Price
T288251-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$345.90
T288251-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$583.90
T288251-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,088.90
T288251-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,741.90

Multikinase degrading PROTAC

View related series

cereblon

Basic Description

Synonyms	N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
Specifications & Purity	≥98%(HPLC)
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Mechanism of action	cereblon

Names and Identifiers

IUPAC Name	N-[2-[2-[2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetamide
INCHI	InChI=1S/C44H51ClN10O9S/c1-28(2)65(61,62)36-9-4-3-7-33(36)50-40-32(45)26-48-44(52-40)49-29-10-12-30(13-11-29)54-19-17-53(18-20-54)21-23-64-25-24-63-22-16-46-38(57)27-47-34-8-5-6-31-39(34)43(60)55(42(31)59)35-14-15-37(56)51-41(35)58/h3-13,26,28,35,47H,14-25,27H2,1-2H3,(H,46,57)(H,51,56,58)(H2,48,49,50,52)
InChi Key	YNGWQHGVASHCBK-UHFFFAOYSA-N
Canonical SMILES	CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=CC=C(C=C3)N4CCN(CC4)CCOCCOCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O
PubChem CID	134812843
Molecular Weight	931.46

PubChem CID

134812843

CAS Registry No.

2250025-88-6

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
E2324486	Certificate of Analysis	Apr 14, 2023	T288251
E2324496	Certificate of Analysis	Apr 14, 2023	T288251
E2324500	Certificate of Analysis	Apr 14, 2023	T288251
E2324502	Certificate of Analysis	Apr 14, 2023	T288251

Solubility

Solvent:DMSO, Max Conc. mg/mL: 93.15, Max Conc. mM: 100

Sensitivity

Moisture & Light sensitive

References

1. Huang HT, Dobrovolsky D, Paulk J, Yang G, Weisberg EL, Doctor ZM, Buckley DL, Cho JH, Ko E, Jang J et al.. (2018) A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.. Cell Chem Biol, 25 (1): (88-99.e6). [PMID:29129717]
2. Riching KM, Schwinn MK, Vasta JD, Robers MB, Machleidt T, Urh M, Daniels DL. (2021) CDK Family PROTAC Profiling Reveals Distinct Kinetic Responses and Cell Cycle-Dependent Degradation of CDK2.. SLAS Discov, 26 (4): (560-569). [PMID:33190579]

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TL 12-186 - ≥98%(HPLC), high purity , CAS No.2250025-88-6, cereblon

Basic Description

Associated Targets

CRBN Tclin Protein cereblon 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

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References

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