Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T288817-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $122.90 | |
T288817-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $189.90 | |
T288817-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $425.90 | |
T288817-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $794.90 | |
T288817-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,429.90 |
Potent MAP4K2 (GCK) inhibitor
Synonyms | 4-Methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]benzamide |
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Specifications & Purity | ≥96%(HPLC) |
Biochemical and Physiological Mechanisms | Potent MAP4K2 (GCK) inhibitor (IC50= 37 nM). Exhibits >70-fold selectivity for MAP4K2 over TAK1 (IC50= 2.7 μM for TAK1). Inhibits IL-1 and TGFβ-induced p38 MAPK phosphorylation,in vitro. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
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IUPAC Name | 4-methyl-3-[6-(methylamino)pyrimidin-4-yl]oxy-N-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]benzamide |
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INCHI | InChI=1S/C25H27F3N6O2/c1-16-4-5-17(10-21(16)36-23-14-22(29-2)30-15-31-23)24(35)32-19-11-18(25(26,27)28)12-20(13-19)34-8-6-33(3)7-9-34/h4-5,10-15H,6-9H2,1-3H3,(H,32,35)(H,29,30,31) |
InChi Key | HXKJJIMUMNPQQY-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3CCN(CC3)C)OC4=NC=NC(=C4)NC |
Isomeric SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3CCN(CC3)C)OC4=NC=NC(=C4)NC |
PubChem CID | 134812827 |
Molecular Weight | 500.53 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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H2402505 | Certificate of Analysis | Apr 15, 2024 | T288817 |
H2402506 | Certificate of Analysis | Apr 15, 2024 | T288817 |
H2402507 | Certificate of Analysis | Apr 15, 2024 | T288817 |
H2402508 | Certificate of Analysis | Apr 15, 2024 | T288817 |
H2402509 | Certificate of Analysis | Apr 15, 2024 | T288817 |
H2402510 | Certificate of Analysis | Apr 15, 2024 | T288817 |
H2402511 | Certificate of Analysis | Apr 15, 2024 | T288817 |
H2402512 | Certificate of Analysis | Apr 15, 2024 | T288817 |
H2402513 | Certificate of Analysis | Apr 15, 2024 | T288817 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 10.01, Max Conc. mM: 20; Solvent:1eq. HCl, Max Conc. mg/mL: 10.01, Max Conc. mM: 20 |
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Sensitivity | Moisture sensitive |