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TL4-12 - ≥96%(HPLC), high purity , CAS No.1620820-12-3

  • ≥96%(HPLC)
Item Number
T288817
Grouped product items
SKUSizeAvailabilityPrice Qty
T288817-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$122.90
T288817-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$189.90
T288817-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$425.90
T288817-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$794.90
T288817-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,429.90

Potent MAP4K2 (GCK) inhibitor

View related series
MAP4K2/GCK inhibitors

Basic Description

Synonyms4-Methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]benzamide
Specifications & Purity≥96%(HPLC)
Biochemical and Physiological MechanismsPotent MAP4K2 (GCK) inhibitor (IC50= 37 nM). Exhibits >70-fold selectivity for MAP4K2 over TAK1 (IC50= 2.7 μM for TAK1). Inhibits IL-1 and TGFβ-induced p38 MAPK phosphorylation,in vitro.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAP4K2 Tchem Mitogen-activated protein kinase kinase kinase kinase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABL2 Tchem Tyrosine-protein kinase ABL2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-methyl-3-[6-(methylamino)pyrimidin-4-yl]oxy-N-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]benzamide
INCHI InChI=1S/C25H27F3N6O2/c1-16-4-5-17(10-21(16)36-23-14-22(29-2)30-15-31-23)24(35)32-19-11-18(25(26,27)28)12-20(13-19)34-8-6-33(3)7-9-34/h4-5,10-15H,6-9H2,1-3H3,(H,32,35)(H,29,30,31)
InChi Key HXKJJIMUMNPQQY-UHFFFAOYSA-N
Canonical SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3CCN(CC3)C)OC4=NC=NC(=C4)NC
Isomeric SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3CCN(CC3)C)OC4=NC=NC(=C4)NC
PubChem CID 134812827
Molecular Weight 500.53

Certificates

Certificate of Analysis(COA)

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9 results found

Lot NumberCertificate TypeDateItem
H2402505Certificate of AnalysisApr 15, 2024 T288817
H2402506Certificate of AnalysisApr 15, 2024 T288817
H2402507Certificate of AnalysisApr 15, 2024 T288817
H2402508Certificate of AnalysisApr 15, 2024 T288817
H2402509Certificate of AnalysisApr 15, 2024 T288817
H2402510Certificate of AnalysisApr 15, 2024 T288817
H2402511Certificate of AnalysisApr 15, 2024 T288817
H2402512Certificate of AnalysisApr 15, 2024 T288817
H2402513Certificate of AnalysisApr 15, 2024 T288817

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 10.01, Max Conc. mM: 20; Solvent:1eq. HCl, Max Conc. mg/mL: 10.01, Max Conc. mM: 20
SensitivityMoisture sensitive

Related Documents

Solution Calculators