TMP920 - 99%, high purity , CAS No.1421837-45-7

Item Number

T647858

Grouped product items
SKU	Size	Availability	Price
T647858-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$190.90
T647858-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$325.90
T647858-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$970.90
T647858-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,650.90

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Basic Description

Specifications & Purity	99%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC 50 of 0.03 μM In Vitro TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Naïve CD4 + T cells. TMP920 suppresses Th17 cell differentiation and lost its IL-17 inhibitory effect at <2.5 μM in vitro. TMP920 suppresses IL-17 production from differentiated Th17 cells in vitro. TMP920 suppresses the Th17 cell transcriptome and promotes alternate T-cell subsets. TMP920 significantly reduces RORγt-DNA interactions. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: Naïve CD4 + T cells Concentration: 0.09-30 μM Incubation Time: 48 hours Result: Has toxic effects on cell growth at >10 μM. Form:Solid IC50& Target:IC50: 0.03 μM (RORγt)

Canonical SMILES

O=C(NC(C1=CC=C(C=C1C)C)C2=CC=CC=C2)CC3=CC=C(C=C3)OCC4=C(ON=C4C)C

Molecular Weight

454.56

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Basic Description