| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| T655202-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $209.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC 50 of 0.03 μM In Vitro TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Naïve CD4 + T cells. TMP920 suppresses Th17 cell differentiation and lost its IL-17 inhibitory effect at <2.5 μM in vitro. TMP920 suppresses IL-17 production from differentiated Th17 cells in vitro. TMP920 suppresses the Th17 cell transcriptome and promotes alternate T-cell subsets. TMP920 significantly reduces RORγt-DNA interactions. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: Naïve CD4 + T cells Concentration: 0.09-30 μM Incubation Time: 48 hours Result: Has toxic effects on cell growth at >10 μM. IC50& Target:IC50: 0.03 μM (RORγt) |
| Canonical SMILES | O=C(NC(C1=CC=C(C=C1C)C)C2=CC=CC=C2)CC3=CC=C(C=C3)OCC4=C(ON=C4C)C |
|---|---|
| Molecular Weight | 454.56 |
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