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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T348407-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $187.90 | |
T348407-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $399.90 | |
T348407-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $599.90 | |
T348407-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $937.90 | |
T348407-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,299.90 |
a TLR7 agonist
Synonyms | 226907-52-4|6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol|TLR7 Ligand II|Toll-Like Receptor 7 Ligand II|SM-360320|SM360320|CHEMBL210884|6-Amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-8H-purin-8-one|6-azanyl-2-(2-methoxyethoxy)-9-(phenylmeth |
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Specifications & Purity | ≥98% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Toll-Like Receptor 7 Ligand II is a cell-permeable hydroxyadenine compound which acts as a potent and highly specific toll-like receptor 7 (TLR7) agonist, without any detectable activity towards TLR2/3/5/8/9. It is shown to be 10-times more potent than R848 in stimulating the production of TLR7-dependent cytokines in cultures|in vitro|.SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. |
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IUPAC Name | 6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8-one |
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INCHI | InChI=1S/C15H17N5O3/c1-22-7-8-23-14-18-12(16)11-13(19-14)20(15(21)17-11)9-10-5-3-2-4-6-10/h2-6H,7-9H2,1H3,(H,17,21)(H2,16,18,19) |
InChi Key | YYCDGEZXHXHLGW-UHFFFAOYSA-N |
Canonical SMILES | COCCOC1=NC(=C2C(=N1)N(C(=O)N2)CC3=CC=CC=C3)N |
Isomeric SMILES | COCCOC1=NC(=C2C(=N1)N(C(=O)N2)CC3=CC=CC=C3)N |
PubChem CID | 10018576 |
Molecular Weight | 315.33 |
Enter Lot Number to search for COA:
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Lot Number | Certificate Type | Date | Item |
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F2404146 | Certificate of Analysis | Feb 29, 2024 | T348407 |
F2404147 | Certificate of Analysis | Feb 29, 2024 | T348407 |
F2404148 | Certificate of Analysis | Feb 29, 2024 | T348407 |
F2404149 | Certificate of Analysis | Feb 29, 2024 | T348407 |
F2404150 | Certificate of Analysis | Feb 29, 2024 | T348407 |
F2404151 | Certificate of Analysis | Feb 29, 2024 | T348407 |
F2404152 | Certificate of Analysis | Feb 29, 2024 | T348407 |
F2404153 | Certificate of Analysis | Feb 29, 2024 | T348407 |
F2404154 | Certificate of Analysis | Feb 29, 2024 | T348407 |
F2404155 | Certificate of Analysis | Feb 29, 2024 | T348407 |
Solubility | Soluble in DMSO or Methanol |
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