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Toll-Like Receptor 7 Ligand II - 98%, high purity , CAS No.226907-52-4

  • ≥98%
Item Number
T348407
Grouped product items
SKUSizeAvailabilityPrice Qty
T348407-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$187.90
T348407-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90
T348407-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$599.90
T348407-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$937.90
T348407-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,299.90

a TLR7 agonist

Basic Description

Synonyms226907-52-4|6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol|TLR7 Ligand II|Toll-Like Receptor 7 Ligand II|SM-360320|SM360320|CHEMBL210884|6-Amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-8H-purin-8-one|6-azanyl-2-(2-methoxyethoxy)-9-(phenylmeth
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Toll-Like Receptor 7 Ligand II is a cell-permeable hydroxyadenine compound which acts as a potent and highly specific toll-like receptor 7 (TLR7) agonist, without any detectable activity towards TLR2/3/5/8/9. It is shown to be 10-times more potent than R848 in stimulating the production of TLR7-dependent cytokines in cultures|in vitro|.SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity.

Associated Targets

TLR8 Tchem Toll-like receptor 8 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NUDT1 Tchem 7,8-dihydro-8-oxoguanine triphosphatase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TLR7 Tclin Toll-like receptor 7 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8-one
INCHI InChI=1S/C15H17N5O3/c1-22-7-8-23-14-18-12(16)11-13(19-14)20(15(21)17-11)9-10-5-3-2-4-6-10/h2-6H,7-9H2,1H3,(H,17,21)(H2,16,18,19)
InChi Key YYCDGEZXHXHLGW-UHFFFAOYSA-N
Canonical SMILES COCCOC1=NC(=C2C(=N1)N(C(=O)N2)CC3=CC=CC=C3)N
Isomeric SMILES COCCOC1=NC(=C2C(=N1)N(C(=O)N2)CC3=CC=CC=C3)N
PubChem CID 10018576
Molecular Weight 315.33

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Certificate of Analysis(COA)

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10 results found

Lot NumberCertificate TypeDateItem
F2404146Certificate of AnalysisFeb 29, 2024 T348407
F2404147Certificate of AnalysisFeb 29, 2024 T348407
F2404148Certificate of AnalysisFeb 29, 2024 T348407
F2404149Certificate of AnalysisFeb 29, 2024 T348407
F2404150Certificate of AnalysisFeb 29, 2024 T348407
F2404151Certificate of AnalysisFeb 29, 2024 T348407
F2404152Certificate of AnalysisFeb 29, 2024 T348407
F2404153Certificate of AnalysisFeb 29, 2024 T348407
F2404154Certificate of AnalysisFeb 29, 2024 T348407
F2404155Certificate of AnalysisFeb 29, 2024 T348407

Chemical and Physical Properties

SolubilitySoluble in DMSO or Methanol

Related Documents

Solution Calculators