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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T413958-1mg | 1mg | In stock | $73.90 | |
T413958-5mg | 5mg | In stock | $206.90 | |
T413958-10mg | 10mg | In stock | $305.90 | |
T413958-25mg | 25mg | In stock | $688.90 | |
T413958-50mg | 50mg | In stock | $939.90 | |
T413958-100mg | 100mg | In stock | $1,335.90 | |
T413958-250mg | 250mg | In stock | $3,006.90 |
eIF Inhibitors
Synonyms | Tomivosertib|eFT508|1849590-01-7|EFT-508|Tomivosertib [INN]|Tomivosertib [USAN]|EFT 508|U2H19X4WBV|6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione|CHEMBL4073443|6'-((6-aminopyrimidin-4-yl)amino)-8'-meth |
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Specifications & Purity | Moligand™, ≥97% |
Biochemical and Physiological Mechanisms | Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramati |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of CDC like kinase 4;Inhibitor of MAPK interacting serine/threonine kinase 1;Inhibitor of MAPK interacting serine/threonine kinase 2;Inhibitor of serine/threonine kinase 17a |
Product Description | Information Tomivosertib (eFT-508) Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance. Targets MNK2 (Cell-free assay); MNK1 (Cell-free assay) 1 nM; 2.4 nM In vitro eFT508 has a half-maximal inhibitory concentration (IC50) of 1-2 nM against both MNK isoforms in enzyme assays and inhibits the kinase through a reversible, ATP-competitive mechanism of action. Treatment of tumor cell lines with eFT508 leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50 = 2-16 nM). In a panel of ~50 hematological cancers, eFT508 shows anti-proliferative activity against multiple DLBCL cell lines. Sensitivity to eFT508 in TMD8, OCI-Ly3 and HBL1 DLBCL cell lines is associated with dose-dependent decreases in production of pro-inflammatory cytokines including TNFα, IL-6, IL-10 and CXCL10. In vivo eFT508 is well-tolerated and shows efficacy against MyD88-mutant DLBCL models in vivo. Significant anti-tumor activity of eFT508 is observed in the TMD8 and HBL-1 ABC-DLBCL models(subcutaneous human lymphoma xenograft models), both of which harbor activating MyD88 mutations. Cell Research(from reference) Cell lines:TMD8 cells Concentrations:0.01, 0.1, 1, 3, 10 μM Incubation Time:24 h |
ALogP | 1.3 |
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IUPAC Name | 6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione |
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INCHI | InChI=1S/C17H20N6O2/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21) |
InChi Key | HKTBYUWLRDZAJK-UHFFFAOYSA-N |
Canonical SMILES | CC1=C2C(=O)NC3(N2C(=O)C(=C1)NC4=NC=NC(=C4)N)CCCCC3 |
Isomeric SMILES | CC1=C2C(=O)NC3(N2C(=O)C(=C1)NC4=NC=NC(=C4)N)CCCCC3 |
Alternate CAS | 1849590-01-7 |
PubChem CID | 118598754 |
MeSH Entry Terms | 6'-((6-Amino-4-pyrimidinyl)amino)-8'-methyl-2'H-spiro(cyclohexane-1,3'-imidazo(1,5-a)pyridine)-1',5'-dione;eFT508;spiro(cyclohexane-1,3'(2'H)-imidazo(1,5-a)pyridine)-1',5'-dione, 6'-((6-amino-4-pyrimidinyl)amino)-8'-methyl-;tomivosertib |
Molecular Weight | 340.38 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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C2302134 | Certificate of Analysis | Sep 24, 2022 | T413958 |
C2303120 | Certificate of Analysis | Sep 24, 2022 | T413958 |
C2303124 | Certificate of Analysis | Sep 24, 2022 | T413958 |
C2303125 | Certificate of Analysis | Sep 24, 2022 | T413958 |
C2303129 | Certificate of Analysis | Sep 24, 2022 | T413958 |
C2303131 | Certificate of Analysis | Sep 24, 2022 | T413958 |
C2303132 | Certificate of Analysis | Sep 24, 2022 | T413958 |
Solubility | Solubility (25°C) In vitro DMSO: 13 mg/mL (38.19 mM); Water: Insoluble; Ethanol: Insoluble; |
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1. Palucka AK, Coussens LM. (2016) The Basis of Oncoimmunology.. Cell, 164 (6): (1233-1247). [PMID:26967289] |
2. Reich SH, Sprengeler PA, Chiang GG, Appleman JR, Chen J, Clarine J, Eam B, Ernst JT, Han Q, Goel VK et al.. (2018) Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.. J Med Chem, 61 (8): (3516-3540). [PMID:29526098] |