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TP508, CAS No.rp175314, Activator of integrin αVβ3

  • Moligand™
Features and benefits
    Item Number
    rp175314
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp175314-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp175314-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90
    View related series
    integrin αVβ3 Activator

    Basic Description

    Product NameTP508, CAS No.rp175314
    SynonymsChrysalin
    GradeMoligand™
    Action TypeACTIVATOR
    Mechanism of actionActivator of integrin αVβ3

    Associated Targets

    ITGB3 Tclin Integrin beta-3 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    ITGAV Tchem Integrin alpha-V 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    CASrp175314

    Certificates

    Certificate of Analysis(COA)

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    Genetic information

    Alternate NamesChrysalin
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Li X, Wang H, Touma E, Qi Y, Rousseau E, Quigg RJ, Ryaby JT.  (2007)  TP508 accelerates fracture repair by promoting cell growth over cell death..  Biochem Biophys Res Commun,  364  (1): (187-93).  [PMID:17942078]
    2. Ryaby JT, Sheller MR, Levine BP, Bramlet DG, Ladd AL, Carney DH.  (2006)  Thrombin peptide TP508 stimulates cellular events leading to angiogenesis, revascularization, and repair of dermal and musculoskeletal tissues..  J Bone Joint Surg Am,  88 Suppl 3  (3): (132-9).  [PMID:17079379]
    3. Tsopanoglou NE, Papaconstantinou ME, Flordellis CS, Maragoudakis ME.  (2004)  On the mode of action of thrombin-induced angiogenesis: thrombin peptide, TP508, mediates effects in endothelial cells via alphavbeta3 integrin..  Thromb Haemost,  92  (4): (846-57).  [PMID:15467917]
    4. Wang H, Li X, Tomin E, Doty SB, Lane JM, Carney DH, Ryaby JT.  (2005)  Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis..  J Orthop Res,  23  (3): (671-9).  [PMID:15885490]
    5. Vartanian KB, Chen HY, Kennedy J, Beck SK, Ryaby JT, Wang H, Hoying JB.  (2006)  The non-proteolytically active thrombin peptide TP508 stimulates angiogenic sprouting..  J Cell Physiol,  206  (1): (175-80).  [PMID:16021627]
    6. Fife C, Mader JT, Stone J, Brill L, Satterfield K, Norfleet A, Zwernemann A, Ryaby JT, Carney DH.  (2007)  Thrombin peptide Chrysalin stimulates healing of diabetic foot ulcers in a placebo-controlled phase I/II study..  Wound Repair Regen,  15  (1): (23-34).  [PMID:17244316]
    7. Derkach DN, Wadekar SA, Perkins KB, Rousseau E, Dreiza CM, Cheung-Flynn J, Ramos HC, Ugarova TP, Sheller MR.  (2010)  RGD-dependent binding of TP508 to integrin alphavbeta3 mediates cell adhesion and induction of nitric oxide..  Thromb Haemost,  104  (1): (172-82).  [PMID:20508901]
    8. Olszewska-Pazdrak B, Carney DH.  (2013)  Systemic administration of thrombin peptide TP508 enhances VEGF-stimulated angiogenesis and attenuates effects of chronic hypoxia..  J Vasc Res,  50  (3): (186-96).  [PMID:23594718]
    9. Olszewska-Pazdrak B, McVicar SD, Rayavara K, Moya SM, Kantara C, Gammarano C, Olszewska P, Fuller GM, Sower LE, Carney DH.  (2016)  Nuclear Countermeasure Activity of TP508 Linked to Restoration of Endothelial Function and Acceleration of DNA Repair..  Radiat Res,  186  (2): (162-174).  [PMID:27388041]
    10. Kantara C, Moya SM, Houchen CW, Umar S, Ullrich RL, Singh P, Carney DH.  (2015)  Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity..  Lab Invest,  95  (11): (1222-33).  [PMID:26280221]

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