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TPBM - ≥97%, high purity , CAS No.6466-43-9

≥97%

CAS#: 6466-43-9
Formula: C₁₅H₁₆N₄O₂S
Molecular Weight: 316.38
PubChem CID: 262425

Item Number

T345098

Grouped product items
SKU	Size	Availability	Price
T345098-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$177.90
T345098-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$318.90
T345098-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$551.90
T345098-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$991.90

a potent inhibitor of estrogen receptor α

View related series

Estrogen Receptor/ERR Vitamin D Related/Nuclear Receptor

Basic Description

Synonyms	TPBM\|6466-43-9\|NSC95910\|8-(benzylsulfanylmethyl)-1,3-dimethyl-7H-purine-2,6-dione\|8-Benzylsulfanylmethyl-1,3-dimethyl-3,7-dihydro-purine-2,6-dione\|MLS002703320\|NSC-95910\|Theophylline, 8-[(benzylthio)methyl]\|NCIStruc1_001567\|NCIStruc2_001461\|SCHEMBL4226426
Specifications & Purity	≥97%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	TPBM is a potent estrogen receptor α (ERα) inhibitor with an IC50 value of 9 μM for 17β-estradiol (E2)-ERα. TPBM reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells (IC50=5 μM). TPBM is not toxic to cells and does not affect estrogen-independent cell growth.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 Activities

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POLI Tchem DNA polymerase iota 0 Activities

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CLPP Tchem ATP-dependent Clp protease proteolytic subunit, mitochondrial 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Discover Target: ALDH1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Discover Target: NFE2L2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	8-(benzylsulfanylmethyl)-1,3-dimethyl-7H-purine-2,6-dione
INCHI	InChI=1S/C15H16N4O2S/c1-18-13-12(14(20)19(2)15(18)21)16-11(17-13)9-22-8-10-6-4-3-5-7-10/h3-7H,8-9H2,1-2H3,(H,16,17)
InChi Key	FEHAMBYTUPDFJE-UHFFFAOYSA-N
Canonical SMILES	CN1C2=C(C(=O)N(C1=O)C)NC(=N2)CSCC3=CC=CC=C3
Isomeric SMILES	CN1C2=C(C(=O)N(C1=O)C)NC(=N2)CSCC3=CC=CC=C3
WGK Germany	3
PubChem CID	262425
Molecular Weight	316.38

Solubility

Soluble in DMSO: >5 mg/mL

Boil Point(°C)

~509.6° C at 760 mmHg (Predicted)

WGK Germany

RIDADR

NONHforallmodesoftransport

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