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TPh A - ≥98%, high purity , CAS No.21306-65-0

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TPh A - ≥98%, high purity , CAS No.21306-65-0

≥98%

CAS#: 21306-65-0
Formula: C₂₁H₂₁NO₃S₂
Molecular Weight: 399.53
PubChem CID: 9583267

Item Number

T274721

Grouped product items
SKU	Size	Availability	Price	Qty
T274721-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$59.90
T274721-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$199.90

Inhibitor of nuclear protein pirin

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Signaling Pathways

Basic Description

Synonyms	TPh A\|21306-65-0\|NPD-123\|N-{[4-(Benzyloxy)phenyl](methyl)-lambda4-sulfanylidene}-4-methylbenzenesulfonamide\|Triphenyl compound A\|CHEMBL1230119\|(NE)-4-methyl-N-[methyl-(4-phenylmethoxyphenyl)-lambda4-sulfanylidene]benzenesulfonamide\|(E)-N-((4-(Benzyloxy)ph
Specifications & Purity	≥98%
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Triphenyl Compound A (TPh A) is an effective inhibitor of nuclear protein pirin, showing specific binding to pirin with a Ki value of 0.6 uM. Its mechanism of action involves disturbing the formation of the bcl3–pirin complex. TPh A serves as a valuable small molecule tool for the regulation of pirin in cellular environments.

Associated Targets

PIR Tchem Pirin 1 Activities

Discover Target: PIR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(NE)-4-methyl-N-[methyl-(4-phenylmethoxyphenyl)-λ4-sulfanylidene]benzenesulfonamide
INCHI	InChI=1S/C21H21NO3S2/c1-17-8-14-21(15-9-17)27(23,24)22-26(2)20-12-10-19(11-13-20)25-16-18-6-4-3-5-7-18/h3-15H,16H2,1-2H3
InChi Key	IMUPOWQOXOCVBN-UHFFFAOYSA-N
Canonical SMILES	CC1=CC=C(C=C1)S(=O)(=O)N=S(C)C2=CC=C(C=C2)OCC3=CC=CC=C3
Isomeric SMILES	CC1=CC=C(C=C1)S(=O)(=O)/N=S(\C)/C2=CC=C(C=C2)OCC3=CC=CC=C3
WGK Germany	3
PubChem CID	9583267
Molecular Weight	399.53

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
E2431513	Certificate of Analysis	May 23, 2024	T274721
E2431514	Certificate of Analysis	May 23, 2024	T274721
E2431515	Certificate of Analysis	May 23, 2024	T274721
E2431516	Certificate of Analysis	May 23, 2024	T274721

Chemical and Physical Properties

Solubility	Soluble in DMSO to 75 mM
Sensitivity	light sensitive

Safety and Hazards(GHS)

WGK Germany	3
RIDADR	NONHforallmodesoftransport

References

1. Tien CP et al.. (2019) Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD.. Aging (Albany NY), 11 (13): (4654-4671). [PMID:31299012]

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