Click Here for 5% Off Your First Aladdin Purchase!

TRAM-34 - ≥98%, high purity , CAS No.289905-88-0, Channel blocker of K Ca3.1

  • Moligand™
  • ≥98%
Item Number
T129575
Grouped product items
SKUSizeAvailabilityPrice Qty
T129575-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$24.90
T129575-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$102.90
T129575-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$195.90
T129575-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$352.90

Potent, selective K Ca 3.1 channel blocker

View related series
KCa3.1 Channel blocker

Basic Description

SynonymsTRAM-34|289905-88-0|1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole|1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole|Tram 34|TRAM34|Triarylmethane-34|C22H17ClN2|1-[(2-chlorophenyl)-diphenylmethyl]pyrazole|CHEMBL498270|CHEBI:34990|1H-Pyrazole, 1-[(2-chlorophe
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPotent, selective K Ca 3.1 channel blocker (IC 50 = 18 nM). Atherosclerosis and immunosuppressive agent. Active in vitro and in vivo .
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeCHANNEL BLOCKER
Mechanism of actionChannel blocker of K Ca3.1
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

TRAM-34 has been shown to be an inhibitor of cloned and native IK1 channels in human T lymphocytes. These K+ channels have been implicated in over-proliferation of cells. Inhibition of IK1 channels has been demonstrated to modulate cell proliferation depending on the concentration of TRAM-34. Mechanistic studies have shown that TRAM-34 may cause a halt in cell growth at the G0/G1 phase.
TRAM-34是一种有效的,选择性的中电导Ca2+-activated K+ channel (IKCa1, KCa3.1)(钙激活的K+通道)抑制剂,Kd为20 nM,比作用于其他离子通道选择性高200到1500倍,且不抑制细胞色素P450。

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RUNX1 Tbio Runt-related transcription factor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FTL Tbio Ferritin light chain 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNA3 Tclin Potassium voltage-gated channel subfamily A member 3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-[(2-chlorophenyl)-diphenylmethyl]pyrazole
INCHI InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
InChi Key KBFUQFVFYYBHBT-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4
Isomeric SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4
WGK Germany 3
PubChem CID 656734
Molecular Weight 344.84

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

1 results found

Lot NumberCertificate TypeDateItem
D1524067Certificate of AnalysisNov 15, 2022 T129575

Chemical and Physical Properties

SolubilitySoluble in DMSO (10 mg/ml at 40°C), ethanol (6 mg/ml at 40°C), and DMF (>25 mg/ml), dichloromethane, ethyl acetate, and methanol. Insoluble in water.

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H413:May cause long lasting harmful effects to aquatic life

H302:Harmful if swallowed

Precautionary Statements

P273:Avoid release to the environment.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3

Related Documents

References

1. Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Köhler R, Miura H, Länger F, Reichenspurner H, Robbins RC et al..  (2013)  The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease..  Transplantation,  95  (2): (285-92).  [PMID:23325003]
2. Yu ZH, Xu JR, Wang YX, Xu GN, Xu ZP, Yang K, Wu DZ, Cui YY, Chen HZ.  (2013)  Targeted inhibition of KCa3.1 channel attenuates airway inflammation and remodeling in allergic asthma..  Am J Respir Cell Mol Biol,  48  (6): (685-93).  [PMID:23492185]
3. Koshy S, Wu D, Hu X, Tajhya RB, Huq R, Khan FS, Pennington MW, Wulff H, Yotnda P, Beeton C.  (2013)  Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes..  PLoS ONE,  (10): (e76740).  [PMID:24146918]
4. Chimote AA, Hajdu P, Kucher V, Boiko N, Kuras Z, Szilagyi O, Yun YH, Conforti L.  (2013)  Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells..  J Immunol,  191  (12): (6273-80).  [PMID:24227782]
5. Chen YJ, Lam J, Gregory CR, Schrepfer S, Wulff H.  (2013)  The Ca²⁺-activated K⁺ channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy..  PLoS ONE,  (11): (e81006).  [PMID:24312257]
6. Roach KM, Duffy SM, Coward W, Feghali-Bostwick C, Wulff H, Bradding P.  (2013)  The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis..  PLoS ONE,  (12): (e85244).  [PMID:24392001]
7. Crottès D, Félix R, Meley D, Chadet S, Herr F, Audiger C, Soriani O, Vandier C, Roger S, Angoulvant D et al..  (2016)  Immature human dendritic cells enhance their migration through KCa3.1 channel activation..  Cell Calcium,  59  (4): (198-207).  [PMID:27020659]
8. Glaser N, Little C, Lo W, Cohen M, Tancredi D, Wulff H, O'Donnell M.  (2017)  Treatment with the KCa3.1 inhibitor TRAM-34 during diabetic ketoacidosis reduces inflammatory changes in the brain..  Pediatr Diabetes,  18  (5): (356-366).  [PMID:27174668]
9. Ohya S, Fukuyo Y, Kito H, Shibaoka R, Matsui M, Niguma H, Maeda Y, Yamamura H, Fujii M, Kimura K et al..  (2014)  Upregulation of KCa3.1 K(+) channel in mesenteric lymph node CD4(+) T lymphocytes from a mouse model of dextran sodium sulfate-induced inflammatory bowel disease..  Am J Physiol Gastrointest Liver Physiol,  306  (10): (G873-85).  [PMID:24674776]
10. Chen YJ, Nguyen HM, Maezawa I, Grössinger EM, Garing AL, Köhler R, Jin LW, Wulff H.  (2016)  The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke..  J Cereb Blood Flow Metab,  36  (12): (2146-2161).  [PMID:26661208]
11. Zhang S, Wang X, Ju C, Zhu L, Du Y, Gao C.  (2016)  Blockage of K(Ca)3.1 and Kv1.3 channels of the B lymphocyte decreases the inflammatory monocyte chemotaxis..  Int Immunopharmacol,  31  (3): (266-71).  [PMID:26795234]
12. Lin H, Zheng C, Li J, Yang C, Hu L.  (2014)  Ca2+ -activated K+ channel-3.1 blocker TRAM-34 alleviates murine allergic rhinitis..  Int Immunopharmacol,  23  (2): (642-8).  [PMID:25466273]
13. Friebel K, Schönherr R, Kinne RW, Kunisch E.  (2015)  Functional role of the KCa3.1 potassium channel in synovial fibroblasts from rheumatoid arthritis patients..  J Cell Physiol,  230  (7): (1677-88).  [PMID:25545021]
14. Shao Z, Gaurav R, Agrawal DK.  (2015)  Intermediate-conductance calcium-activated potassium channel KCa3.1 and chloride channel modulate chemokine ligand (CCL19/CCL21)-induced migration of dendritic cells..  Transl Res,  166  (1): (89-102).  [PMID:25583444]

Solution Calculators