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Home Bioactive Small Molecules Trametinib DMSO solvate - 99%, high purity , Dual specificity mitogen-activated protein kinase kinase 1 inhibitor, CAS No.1187431-43-1, Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
Trametinib DMSO solvate - 99%, high purity , Dual specificity mitogen-activated protein kinase kinase 1 inhibitor, CAS No.1187431-43-1, Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
MEK1 Selective Inhibitors
Basic Description Synonyms JTP-74057 (DMSO solvate) | AS-17069 | GSK-1120212 (DMSO solvate) | 1187431-43-1 | N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide compound with (methylsulfin Specifications & Purity ≥99% Biochemical and Physiological Mechanisms Trametinib (GSK1120212, JTP-74057, Mekinist) DMSO solvate is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assay. Trametinib activates autophagy and induces apoptosis. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Action Type INHIBITOR Mechanism of action Dual specificity mitogen-activated protein kinase kinase 1 inhibitor Product Description Information
Trametinib (GSK1120212, JTP-74057, Mekinist) DMSO solvate is a highly specific and potentMEK1/2inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assay. Trametinib activatesautophagyand inducesapoptosis.
Targets
MEK1 (Cell-free assay); MEK2 (Cell-free assay) 0.92 nM; 1.8 nM
Product Properties ALogP 2.86 HBD Count 2 Rotatable Bond 5
Names and Identifiers IUPAC Name N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide;methylsulfinylmethane INCHI InChI=1S/C26H23FIN5O4.C2H6OS/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34;1-4(2)3/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34);1-2H3 InChi Key OQUFJVRYDFIQBW-UHFFFAOYSA-N Canonical SMILES CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5.CS(=O)C Isomeric SMILES CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5.CS(=O)C PubChem CID 50992434 Molecular Weight 693.53
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 50 mg/mL (72.09 mM); Water: Insoluble; Ethanol: Insoluble; DMSO(mg / mL) Max Solubility 50 DMSO(mM) Max Solubility 72.0949346098943 Water(mg / mL) Max Solubility ＜1
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
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