| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| T420824-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $241.90 |
MEK1 Selective Inhibitors
| Synonyms | 1187431-43-1|Trametinib DMSO solvate|TRAMETINIB DIMETHYL SULFOXIDE|Trametinib DMSO|GSK1120212B|Mekinst|Trametinib (DMSO solvate)|UNII-BSB9VJ5TUT|BSB9VJ5TUT|CHEBI:75991|GSK-1120212B|Trametinib dimethyl sulfoxide [USAN]|DTXSID30152223|N-(3-(3-Cyclopropyl-5- |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information Trametinib (GSK1120212, JTP-74057, Mekinist) DMSO solvate is a highly specific and potentMEK1/2inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assay. Trametinib activatesautophagyand inducesapoptosis. Targets MEK1 (Cell-free assay); MEK2 (Cell-free assay) 0.92 nM; 1.8 nM |
| ALogP | 2.86 |
|---|---|
| HBD Count | 2 |
| Rotatable Bond | 5 |
| IUPAC Name | N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide;methylsulfinylmethane |
|---|---|
| INCHI | InChI=1S/C26H23FIN5O4.C2H6OS/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34;1-4(2)3/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34);1-2H3 |
| InChi Key | OQUFJVRYDFIQBW-UHFFFAOYSA-N |
| Canonical SMILES | CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5.CS(=O)C |
| Isomeric SMILES | CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5.CS(=O)C |
| PubChem CID | 50992434 |
| Molecular Weight | 693.53 |
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| DMSO(mg / mL) Max Solubility | 50 |
|---|---|
| DMSO(mM) Max Solubility | 72.0949346098943 |
| Water(mg / mL) Max Solubility | ＜1 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
