trans-Pralsetinib - 96%, high purity , Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET inhibitor, CAS No.2097132-93-7, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET inhibitor

Item Number

T651511

Grouped product items
SKU	Size	Availability	Price
T651511-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$130.90
T651511-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$185.90
T651511-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$685.90
T651511-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,080.90

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Basic Description

Synonyms	Pralsetinib\|BLU-667\|2097132-94-8\|Pralsetinib free base\|Gavreto\|Blu667\|trans-Pralsetinib\|Pralsetinib [INN]\|Pralsetinib [USAN]\|BLU123244\|BLU-667 (Pralsetinib)\|1WPE73O1WV\|N-[(1S)-1-[6-(4-fluoropyrazol-1-yl)pyridin-3-yl]ethyl]-1-methoxy-4-[4-methyl-6-[(5-meth
Specifications & Purity	96%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET inhibitor
Product Description	trans-Pralsetinib (trans-BLU-667) is a rearranged during transfection (RET) inhibitor extracted from patent US20170121312A1, Compound Example 129 Form:Solid IC50& Target:RET

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[(1S)-1-[6-(4-fluoropyrazol-1-yl)pyridin-3-yl]ethyl]-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxamide
INCHI	InChI=1S/C27H32FN9O2/c1-16-11-22(33-23-12-17(2)35-36-23)34-25(31-16)19-7-9-27(39-4,10-8-19)26(38)32-18(3)20-5-6-24(29-13-20)37-15-21(28)14-30-37/h5-6,11-15,18-19H,7-10H2,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t18-,19?,27?/m0/s1
InChi Key	GBLBJPZSROAGMF-SIYOEGHHSA-N
Canonical SMILES	CC1=CC(=NN1)NC2=NC(=NC(=C2)C)C3CCC(CC3)(C(=O)NC(C)C4=CN=C(C=C4)N5C=C(C=N5)F)OC
Isomeric SMILES	CC1=CC(=NN1)NC2=NC(=NC(=C2)C)C3CCC(CC3)(C(=O)N[C@@H](C)C4=CN=C(C=C4)N5C=C(C=N5)F)OC
Alternate CAS	2097132-94-8
PubChem CID	129073603
MeSH Entry Terms	BLU-667;Cyclohexanecarboxamide, N-((1S)-1-(6-(4-fluoro-1H-pyrazol-1-yl)-3-pyridinyl)ethyl)-1-methoxy-4-(4-methyl-6-((5-methyl-1H-pyrazol-3-yl)amino)-2-pyrimidinyl)-, trans-;gavreto;pralsetinib;trans-N-((1S)-1-(6-(4-Fluoro-1H-pyrazol-1-yl)-3-pyridinyl)ethy
Molecular Weight	533.60

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Basic Description