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Triptolide - 98%, high purity , CAS No.38748-32-2
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
Basic Description Synonyms triptolide|38748-32-2|Triptolid|PG490|NSC 163062|NSC-163062|19ALD1S53J|CHEBI:9747|CHEMBL463763|PG-490|(1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-17-one|(3b Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Inhibits DNA-dependent ATPase activity of XBP and induces inhibition of RNA polymerase II (RNAPII)-mediated transcription (IC50= 200 nM). Selective for RNAPII over RNAPI and RNAPIII. Blocks RNA synthesis in HeLa cells (IC50= 62 nM); exhibits potent antipr Storage Temp Store at 2-8°C Shipped In Wet ice
Names and Identifiers IUPAC Name (1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-17-one INCHI InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1 InChi Key DFBIRQPKNDILPW-CIVMWXNOSA-N Canonical SMILES CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C Isomeric SMILES CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C WGK Germany 3 RTECS YK7751000 PubChem CID 107985 Molecular Weight 360.4 Reaxy-Rn 1692435
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 7.21, Max Conc. mM: 20 Sensitivity Heat Sensitive Melt Point(°C) 229 °C
Safety and Hazards(GHS) Pictogram(s) GHS06 , GHS08 Signal Danger Hazard Statements H301: Toxic if swallowed
H300: Fatal if swallowed
H330: Fatal if inhaled
H300+H330: Fatal if swallowed or if inhaled
H361: Suspected of damaging fertility or the unborn child
H361f: Suspected of damaging fertility
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P284: [In case of inadequate ventilation] Wear respiratory protection.
P271: Use only outdoors or in a well-ventilated area.
P270: Do not eat, drink or smoke when using this product.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P330: Rinse mouth.
P320: Specific treatment is urgent (see ... on this label).
P203: Obtain, read and follow all safety instructions before use.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
P318: if exposed or concerned, get medical advice.
P316: Get emergency medical help immediately.
WGK Germany 3 RTECS YK7751000 Reaxy-Rn 1692435 Merck Index 9747
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H2302761