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Tris(2-carboxyethyl)phosphine hydrochloride - 98%, high purity , CAS No.51805-45-9

≥98%

CAS#: 51805-45-9
Formula: C₉H₁₅O₆P·HCl
Molecular Weight: 286.65
Beilstein Registry Number: 3724376
MDL number: MFCD00145469
PubChem CID: 2734570

Item Number

T107252

Grouped product items
SKU	Size	Availability	Price
T107252-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$12.90
T107252-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$16.90
T107252-10g	10g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$30.90
T107252-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$61.90
T107252-100g	100g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$199.90
T107252-500g	500g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$639.90

Non-thiol reducing reagent

View related series

Bioconjugation Element classified compounds Phosphorus-containing compounds Reduction reaction

Basic Description

Synonyms	Tris(2-carboxyethyl)phosphine hydrochloride \| TCEP (hydrochloride) \| TRIS(2-CARBOXYETHYL)PHOSPHINE HCL \| TCEP HCl \| Tcep hydrochloride [MI] \| 3,3',3''-Phosphinetriyltripropanoic acid hydrochloride \| 3,3',3''-Phosphinetriyltripropanoic acid HCl \| 3-[bis(2-
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Non-thiol reducing reagent. Reduces dehydroascorbic acid at low pH more efficiently than DTT. Reductive at pH 1.5 to pH 9.0. Reverses Mg 2+ inibition of NFκB-DNA binding.
Storage Temp	Store at 2-8°C,Protected from light,Argon charged
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	TCEP Hydrochloride is a water soluble, non-thiol, strong reducing agent shown to cleave disulfide bonds. Reports indicate that TCEP Hydrochloride can rapidly reduce stable alkyl disulfides, including DTT. Application： Tris(2-carboxyethyl)phosphine hydrochloride (TCEP. HCl) can be used: As a reducing agent for the reduction of sulfoxides, sulfonyl chlorides, N-oxides, and azides. It can also be used in azide-alkyne cycloaddition reaction in the presence of a copper catalyst. To reduce disulfide bonds in various proteins. As a reagent for the selective reduction of disulfides in water. To remove ruthenium-derived metathesis catalysts via aqueous washing of a crude reaction mixture when it is basified. As a reducing agent for the reduction of various alkyl disulfides such as trans-4,5-dihydroxy-1,2-dithiane. Water soluble reagent, used for selective reduction of disulfides. More stable than DTT and useful in mass spectrometry applications.

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC1 Tclin Histone deacetylase 1 0 Activities

Discover Target: HDAC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-[bis(2-carboxyethyl)phosphanyl]propanoic acid;hydrochloride
INCHI	InChI=1S/C9H15O6P.ClH/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15;/h1-6H2,(H,10,11)(H,12,13)(H,14,15);1H
InChi Key	PBVAJRFEEOIAGW-UHFFFAOYSA-N
Canonical SMILES	C(CP(CCC(=O)O)CCC(=O)O)C(=O)O.Cl
Isomeric SMILES	C(CP(CCC(=O)O)CCC(=O)O)C(=O)O.Cl
WGK Germany	2
PubChem CID	2734570
UN Number	3261
Packing Group	II
Molecular Weight	286.65
Beilstein	3724376
Reaxy-Rn	3724376

Certificates

Certificate of Analysis(COA)

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44 results found

Lot Number	Certificate Type	Date	Item
G2409150	Certificate of Analysis	Jun 27, 2024	T107252
G2409149	Certificate of Analysis	Jun 27, 2024	T107252
G2409148	Certificate of Analysis	Jun 27, 2024	T107252
G2409136	Certificate of Analysis	Jun 27, 2024	T107252
G2214357	Certificate of Analysis	Apr 26, 2024	T107252
G2214345	Certificate of Analysis	Apr 26, 2024	T107252
F2210008	Certificate of Analysis	Mar 19, 2024	T107252
F2209402	Certificate of Analysis	Mar 19, 2024	T107252
D2417550	Certificate of Analysis	Mar 14, 2024	T107252
D2417551	Certificate of Analysis	Mar 14, 2024	T107252
D2417552	Certificate of Analysis	Mar 14, 2024	T107252
B2422210	Certificate of Analysis	Feb 01, 2024	T107252
F2413078	Certificate of Analysis	Feb 01, 2024	T107252
B2427250	Certificate of Analysis	Feb 01, 2024	T107252
B2422209	Certificate of Analysis	Feb 01, 2024	T107252
B2422211	Certificate of Analysis	Feb 01, 2024	T107252
B2422214	Certificate of Analysis	Feb 01, 2024	T107252
B2422212	Certificate of Analysis	Feb 01, 2024	T107252
B2422213	Certificate of Analysis	Feb 01, 2024	T107252
L2308425	Certificate of Analysis	Nov 22, 2023	T107252
L2308424	Certificate of Analysis	Nov 22, 2023	T107252
L2308421	Certificate of Analysis	Nov 22, 2023	T107252
L2308420	Certificate of Analysis	Nov 22, 2023	T107252
L2308417	Certificate of Analysis	Nov 22, 2023	T107252
L2308414	Certificate of Analysis	Nov 22, 2023	T107252
H2328335	Certificate of Analysis	Aug 16, 2023	T107252
H2328336	Certificate of Analysis	Aug 16, 2023	T107252
H2328337	Certificate of Analysis	Aug 16, 2023	T107252
H2328366	Certificate of Analysis	Aug 16, 2023	T107252
H2328610	Certificate of Analysis	Aug 16, 2023	T107252
J2115287	Certificate of Analysis	Jul 11, 2023	T107252
D2112043	Certificate of Analysis	Jan 13, 2023	T107252
K2020171	Certificate of Analysis	Sep 13, 2022	T107252
G2304018	Certificate of Analysis	May 31, 2022	T107252
F2330042	Certificate of Analysis	May 31, 2022	T107252
G2214339	Certificate of Analysis	May 31, 2022	T107252
G2214348	Certificate of Analysis	May 31, 2022	T107252
K2317136	Certificate of Analysis	May 31, 2022	T107252
K2317055	Certificate of Analysis	May 31, 2022	T107252
G2214349	Certificate of Analysis	May 31, 2022	T107252
G2214350	Certificate of Analysis	May 31, 2022	T107252
G23261136	Certificate of Analysis	May 31, 2022	T107252
F2210009	Certificate of Analysis	May 31, 2022	T107252
E2209216	Certificate of Analysis	May 17, 2022	T107252

Chemical and Physical Properties

Solubility	Soluble in water (5 mg/ml), and methanol., Soluble in water (5 mg/ml), and methanol.
Sensitivity	Moisture & Air & Light Sensitive
Refractive Index	n20/D 1.367
Melt Point(°C)	177°C

Safety and Hazards(GHS)

Pictogram(s)	GHS05
Signal	Danger
Hazard Statements	H314:Causes severe skin burns and eye damage
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately.
WGK Germany	2
Reaxy-Rn	3724376
Class	8
Merck Index	9085

Alternative Products

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