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trodusquemine , CAS No.186139-09-3, Inhibitor of protein tyrosine phosphatase non-receptor type 1

trodusquemine , CAS No.186139-09-3, Inhibitor of protein tyrosine phosphatase non-receptor type 1

Item Number

T614547

Grouped product items
SKU	Size	Availability	Price	Qty
T614547-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90
T614547-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,001.90

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Basic Description

Synonyms	Trodusquemine\|MSI-1436\|186139-09-3\|KKC12PIF16\|CHEMBL508583\|Produlestan\|Trodulamine\|Trodusquemine [USAN]\|UNII-KKC12PIF16\|Trodusquemine [USAN:INN]\|MSI1436\|(24R)-3beta-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)amino)-7alpha-hydroxy-5alpha-cholestan-24
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of protein tyrosine phosphatase non-receptor type 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	[(3R,6R)-6-[(3S,5R,7R,8R,9S,10S,13R,14S,17R)-3-[3-[4-(3-aminopropylamino)butylamino]propylamino]-7-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptan-3-yl] hydrogen sulfate
INCHI	InChI=1S/C37H72N4O5S/c1-26(2)34(46-47(43,44)45)13-10-27(3)30-11-12-31-35-32(15-17-37(30,31)5)36(4)16-14-29(24-28(36)25-33(35)42)41-23-9-22-40-20-7-6-19-39-21-8-18-38/h26-35,39-42H,6-25,38H2,1-5H3,(H,43,44,45)/t27-,28-,29+,30-,31+,32+,33-,34-,35+,36+,37-/m1/s1
InChi Key	WUJVPODXELZABP-FWJXURDUSA-N
Canonical SMILES	CC(C)C(CCC(C)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)NCCCNCCCCNCCCN)C)O)C)OS(=O)(=O)O
Isomeric SMILES	C[C@H](CC[C@H](C(C)C)OS(=O)(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C[C@@H]4[C@@]3(CC[C@@H](C4)NCCCNCCCCNCCCN)C)O)C
Alternate CAS	186139-09-3
PubChem CID	9917968
MeSH Entry Terms	3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate;3beta-N-1(spermine)-7alpha, 24R-dihydroxy-5alpha-cholestane 24-sulfate;MSI 1436;MSI1436;trodusquemine
Molecular Weight	685.07

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1. Lantz KA, Hart SG, Planey SL, Roitman MF, Ruiz-White IA, Wolfe HR, McLane MP. (2010) Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice.. Obesity (Silver Spring), 18 (8): (1516-23). [PMID:20075852]

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