Protected from light,Argon charged,Desiccated,Store at -80°C
Shipped In
Ice chest + Ice pads
Product Description
TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists.
In Vitro
TRV056 is a “gain-of-function” ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), “Gq-biased” AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
Names and Identifiers
Molecular Weight
1103.23
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
Solubility
H2O : 1.96 mg/mL (1.78 mM; ultrasonic and adjust pH to 2 with HCl)