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TUG-1375 , CAS No.T614580, Agonist of FFA2 receptor

Item Number

T614580

Grouped product items
SKU	Size	Availability	Price	Qty
T614580-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$324.90
T614580-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$830.90

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Basic Description

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	(2R,4R)-2-(2-chlorophenyl)-3-(4-(3,5-dimethylisoxazol-4-yl)benzoyl)thiazolidine-4-carboxylic acid
INCHI	InChI=1S/C22H19ClN2O4S/c1-12-19(13(2)29-24-12)14-7-9-15(10-8-14)20(26)25-18(22(27)28)11-30-21(25)16-5-3-4-6-17(16)23/h3-10,18,21H,11H2,1-2H3,(H,27,28)/t18-,21+/m1/s1
InChi Key	RZAMDGBOOPJHJQ-NQIIRXRSSA-N
Canonical SMILES	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C
PubChem CID	137321147

GPCRdb Ligand	TUG-1375
PubChem CID	137321147

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1. Le Poul E, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, Brezillon S, Dupriez V, Vassart G, Van Damme J et al.. (2003) Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.. J Biol Chem, 278 (28): (25481-9). [PMID:12711604]
2. Ulven T. (2012) Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets.. Front Endocrinol (Lausanne), 3 (3): (111). [PMID:23060857]
3. Hansen AH, Sergeev E, Bolognini D, Sprenger RR, Ekberg JH, Ejsing CS, McKenzie CJ, Rexen Ulven E, Milligan G, Ulven T. (2018) Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties.. J Med Chem, 61 (21): (9534-9550). [PMID:30247908]

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